Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials
The DNA vaccine, AV-1959D, targeting N-terminal epitope of Aβ peptide, has been proven immunogenic in mice, rabbits, and non-human primates, while its therapeutic efficacy has been shown in mouse models of Alzheimer's disease (AD). Here we report for the first time on IND-enabling biodistributi...
Main Authors: | Irina Petrushina, Armine Hovakimyan, Indira S. Harahap-Carrillo, Hayk Davtyan, Tatevik Antonyan, Gor Chailyan, Konstantin Kazarian, Maxim Antonenko, Amandine Jullienne, Mary M. Hamer, Andre Obenaus, Olga King, Karen Zagorski, Mathew Blurton-Jones, David H. Cribbs, Harry Lander, Anahit Ghochikyan, Michael G. Agadjanyan |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612030098X |
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