The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice

• Main Authors: Masoumeh Asadi Motlagh, Bahareh Pakpour, Majid Navaian
• Format: Article
• Language: fas
• Published: Kashan University of Medical Sciences and Health Services 2018-08-01
• Series: Fiyz̤
• Subjects: 5-HT3; Ethanol; Passive avoidance memory; Hippocapus; Mice
• Online Access: http://feyz.kaums.ac.ir/article-1-3538-en.html
• ISSN: 1029-7855; 2008-9821

Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory. Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used. Results: Results showed that pre-training injection of ethanol (1mg/kg), and MCHL (0.5 ng/mouse) decreased a passive avoidance memory in the adult mice. Also, a non- effective dose of MCHL (0.005 ng/mouse) with a non- effective dose of ethanol (0.01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0.5, 0.05, and 0.005 ng/mouse) combined with an effective dose of ethanol (1mg/kg) could retrieve damaged memory by ethanol. Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol.