The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice
Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory. Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL)...
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Kashan University of Medical Sciences and Health Services
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doaj-89f899ec26144d3cb2989bcacb1b9c352020-11-24T22:24:46Zfas Kashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212018-08-01223239247The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in miceMasoumeh Asadi Motlagh0 Bahareh Pakpour1 Majid Navaian2Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, I. R. Iran.Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, I. R. Iran.Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, I. R. Iran.Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory. Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used. Results: Results showed that pre-training injection of ethanol (1mg/kg), and MCHL (0.5 ng/mouse) decreased a passive avoidance memory in the adult mice. Also, a non- effective dose of MCHL (0.005 ng/mouse) with a non- effective dose of ethanol (0.01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0.5, 0.05, and 0.005 ng/mouse) combined with an effective dose of ethanol (1mg/kg) could retrieve damaged memory by ethanol. Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol.http://feyz.kaums.ac.ir/article-1-3538-en.html5-HT3EthanolPassive avoidance memoryHippocapusMice |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Masoumeh Asadi Motlagh Bahareh Pakpour Majid Navaian |
spellingShingle |
Masoumeh Asadi Motlagh Bahareh Pakpour Majid Navaian The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice Fiyz̤ 5-HT3 Ethanol Passive avoidance memory Hippocapus Mice |
author_facet |
Masoumeh Asadi Motlagh Bahareh Pakpour Majid Navaian |
author_sort |
Masoumeh Asadi Motlagh |
title |
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
title_short |
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
title_full |
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
title_fullStr |
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
title_full_unstemmed |
The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
title_sort |
effect of 5-ht3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice |
publisher |
Kashan University of Medical Sciences and Health Services |
series |
Fiyz̤ |
issn |
1029-7855 2008-9821 |
publishDate |
2018-08-01 |
description |
Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory.
Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used.
Results: Results showed that pre-training injection of ethanol (1mg/kg), and MCHL (0.5 ng/mouse) decreased a passive avoidance memory in the adult mice. Also, a non- effective dose of MCHL (0.005 ng/mouse) with a non- effective dose of ethanol (0.01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0.5, 0.05, and 0.005 ng/mouse) combined with an effective dose of ethanol (1mg/kg) could retrieve damaged memory by ethanol.
Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol. |
topic |
5-HT3 Ethanol Passive avoidance memory Hippocapus Mice |
url |
http://feyz.kaums.ac.ir/article-1-3538-en.html |
work_keys_str_mv |
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