Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation

Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation

Antibodies leverage on their unique architecture to bind with an array of antigens. The strength of interaction has a direct relation to the affinity of the antibodies towards the antigen. <i>In vivo</i> affinity maturation is performed through multiple rounds of somatic hypermutation an...

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Bibliographic Details
Main Authors: Chia Chiu Lim, Yee Siew Choong, Theam Soon Lim
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
human monoclonal antibodies
phage display
combinatorial libraries
affinity maturation
Online Access:https://www.mdpi.com/1422-0067/20/8/1861

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