Nuclear Receptors in Nonalcoholic Fatty Liver Disease
Nuclear receptors comprise a superfamily of ligand-activated transcription factors that are involved in important aspects of hepatic physiology and pathophysiology. There are about 48 nuclear receptors in the human. These nuclear receptors are regulators of many hepatic processes including hepatic l...
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doaj-89ff193c036f40249250b33cc3dea68c2020-11-24T21:02:56ZengHindawi LimitedJournal of Lipids2090-30302090-30492012-01-01201210.1155/2012/139875139875Nuclear Receptors in Nonalcoholic Fatty Liver DiseaseJorge A. López-Velázquez0Luis D. Carrillo-Córdova1Norberto C. Chávez-Tapia2Misael Uribe3Nahum Méndez-Sánchez4Liver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Colonia Toriello Guerra, 14050 Tlalpan, Mexico City, MexicoLiver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Colonia Toriello Guerra, 14050 Tlalpan, Mexico City, MexicoLiver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Colonia Toriello Guerra, 14050 Tlalpan, Mexico City, MexicoLiver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Colonia Toriello Guerra, 14050 Tlalpan, Mexico City, MexicoLiver Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150, Colonia Toriello Guerra, 14050 Tlalpan, Mexico City, MexicoNuclear receptors comprise a superfamily of ligand-activated transcription factors that are involved in important aspects of hepatic physiology and pathophysiology. There are about 48 nuclear receptors in the human. These nuclear receptors are regulators of many hepatic processes including hepatic lipid and glucose metabolism, bile acid homeostasis, drug detoxification, inflammation, regeneration, fibrosis, and tumor formation. Some of these receptors are sensitive to the levels of molecules that control lipid metabolism including fatty acids, oxysterols, and lipophilic molecules. These receptors direct such molecules to the transcriptional networks and may play roles in the pathogenesis and treatment of nonalcoholic fatty liver disease. Understanding the mechanisms underlying the involvement of nuclear receptors in the pathogenesis of nonalcoholic fatty liver disease may offer targets for the development of new treatments for this liver disease.http://dx.doi.org/10.1155/2012/139875 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jorge A. López-Velázquez Luis D. Carrillo-Córdova Norberto C. Chávez-Tapia Misael Uribe Nahum Méndez-Sánchez |
spellingShingle |
Jorge A. López-Velázquez Luis D. Carrillo-Córdova Norberto C. Chávez-Tapia Misael Uribe Nahum Méndez-Sánchez Nuclear Receptors in Nonalcoholic Fatty Liver Disease Journal of Lipids |
author_facet |
Jorge A. López-Velázquez Luis D. Carrillo-Córdova Norberto C. Chávez-Tapia Misael Uribe Nahum Méndez-Sánchez |
author_sort |
Jorge A. López-Velázquez |
title |
Nuclear Receptors in Nonalcoholic Fatty Liver Disease |
title_short |
Nuclear Receptors in Nonalcoholic Fatty Liver Disease |
title_full |
Nuclear Receptors in Nonalcoholic Fatty Liver Disease |
title_fullStr |
Nuclear Receptors in Nonalcoholic Fatty Liver Disease |
title_full_unstemmed |
Nuclear Receptors in Nonalcoholic Fatty Liver Disease |
title_sort |
nuclear receptors in nonalcoholic fatty liver disease |
publisher |
Hindawi Limited |
series |
Journal of Lipids |
issn |
2090-3030 2090-3049 |
publishDate |
2012-01-01 |
description |
Nuclear receptors comprise a superfamily of ligand-activated transcription factors that are involved in important aspects of hepatic physiology and pathophysiology. There are about 48 nuclear receptors in the human. These nuclear receptors are regulators of many hepatic processes including hepatic lipid and glucose metabolism, bile acid homeostasis, drug detoxification, inflammation, regeneration, fibrosis, and tumor formation. Some of these receptors are sensitive to the levels of molecules that control lipid metabolism including fatty acids, oxysterols, and lipophilic molecules. These receptors direct such molecules to the transcriptional networks and may play roles in the pathogenesis and treatment of nonalcoholic fatty liver disease. Understanding the mechanisms underlying the involvement of nuclear receptors in the pathogenesis of nonalcoholic fatty liver disease may offer targets for the development of new treatments for this liver disease. |
url |
http://dx.doi.org/10.1155/2012/139875 |
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