Experimental determination of the oral bioavailability and bioaccessibility of lead particles

• Main Authors: Deshommes Elise, Tardif Robert, Edwards Marc, Sauvé Sébastien, Prévost Michèle
• Format: Article
• Language: English
• Published: BMC 2012-11-01
• Series: Chemistry Central Journal
• Subjects: Oral bioavailability; Bioaccessibility; Lead [Pb] particles; <it>In vivo</it> tests; <it>In vitro</it> tests
• Online Access: http://journal.chemistrycentral.com/content/6/1/138

<p>Abstract</p> <p><it>In vivo</it> estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is <it>in vitro</it> testing. This testing method requires calibration using <it>in vivo</it> data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with <it>in vivo</it> data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.</p>