Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

Macrophages exposed to the Th2 cytokines interleukin (IL) IL-4 and IL-13 exhibit a distinct transcriptional response, commonly referred to as M2 polarization. Recently, IL-4-induced polarization of murine bone marrow-derived macrophages (BMDMs) has been linked to acetyl-CoA levels through the activi...

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Bibliographic Details
Main Authors: Dmitry Namgaladze, Sven Zukunft, Frank Schnütgen, Nina Kurrle, Ingrid Fleming, Dominik Fuhrmann, Bernhard Brüne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
macrophage
ATP-citrate lyase
acetyl-CoA
interleukin-4
histone acetylation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02858/full

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