A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells

Antibody-based therapies hold promise for a safe and efficient treatment of cancer. The identification of target tumor cells through a specific antigen enriched on their surface and the subsequent delivery of the therapeutic agent only to those cells requires, besides the efficacy of the therapeutic...

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Bibliographic Details
Main Authors: Franziska Hartung, Thomas Krüwel, Xiaoyi Shi, Klaus Pfizenmaier, Roland Kontermann, Patrick Chames, Frauke Alves, Luis A. Pardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
targeted therapy
nanobody
TRAIL
Kv10.1
voltage-gated potassium channel
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00686/full

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