Stress amplifies sex differences in primate prefrontal profiles of gene expression
Abstract Background Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of ge...
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doaj-8a2090d27a414bc0bcb8b3d756dff8022020-11-24T23:01:25ZengBMCBiology of Sex Differences2042-64102017-11-018111110.1186/s13293-017-0157-3Stress amplifies sex differences in primate prefrontal profiles of gene expressionAlex G. Lee0Megan Hagenauer1Devin Absher2Kathleen E. Morrison3Tracy L. Bale4Richard M. Myers5Stanley J. Watson6Huda Akil7Alan F. Schatzberg8David M. Lyons9Department of Psychiatry and Behavioral Sciences, Stanford UniversityMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of MichiganHudsonAlpha Institute for BiotechnologyDepartment of Animal Biology, University of PennsylvaniaDepartment of Animal Biology, University of PennsylvaniaHudsonAlpha Institute for BiotechnologyMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of MichiganMolecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of MichiganDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityDepartment of Psychiatry and Behavioral Sciences, Stanford UniversityAbstract Background Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of gene expression in squirrel monkey adults. Methods Dorsolateral, ventrolateral, and ventromedial prefrontal cortical regions from 18 females and 12 males were collected after stress or no-stress treatment conditions. Gene expression profiles were acquired using HumanHT-12v4.0 Expression BeadChip arrays adapted for squirrel monkeys. Results Extensive variation between prefrontal cortical regions was discerned in the expression of numerous autosomal and sex chromosome genes. Robust sex differences were also identified across prefrontal cortical regions in the expression of mostly autosomal genes. Genes with increased expression in females compared to males were overrepresented in mitogen-activated protein kinase and neurotrophin signaling pathways. Many fewer genes with increased expression in males compared to females were discerned, and no molecular pathways were identified. Effect sizes for sex differences were greater in stress compared to no-stress conditions for ventromedial and ventrolateral prefrontal cortical regions but not dorsolateral prefrontal cortex. Conclusions Stress amplifies sex differences in gene expression profiles for prefrontal cortical regions involved in stress coping and emotion regulation. Results suggest molecular targets for new treatments of stress disorders in human mental health.http://link.springer.com/article/10.1186/s13293-017-0157-3Social stressSex biasedPrefrontal cortexGene expression profilingNeurotrophinsMAPK signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alex G. Lee Megan Hagenauer Devin Absher Kathleen E. Morrison Tracy L. Bale Richard M. Myers Stanley J. Watson Huda Akil Alan F. Schatzberg David M. Lyons |
spellingShingle |
Alex G. Lee Megan Hagenauer Devin Absher Kathleen E. Morrison Tracy L. Bale Richard M. Myers Stanley J. Watson Huda Akil Alan F. Schatzberg David M. Lyons Stress amplifies sex differences in primate prefrontal profiles of gene expression Biology of Sex Differences Social stress Sex biased Prefrontal cortex Gene expression profiling Neurotrophins MAPK signaling |
author_facet |
Alex G. Lee Megan Hagenauer Devin Absher Kathleen E. Morrison Tracy L. Bale Richard M. Myers Stanley J. Watson Huda Akil Alan F. Schatzberg David M. Lyons |
author_sort |
Alex G. Lee |
title |
Stress amplifies sex differences in primate prefrontal profiles of gene expression |
title_short |
Stress amplifies sex differences in primate prefrontal profiles of gene expression |
title_full |
Stress amplifies sex differences in primate prefrontal profiles of gene expression |
title_fullStr |
Stress amplifies sex differences in primate prefrontal profiles of gene expression |
title_full_unstemmed |
Stress amplifies sex differences in primate prefrontal profiles of gene expression |
title_sort |
stress amplifies sex differences in primate prefrontal profiles of gene expression |
publisher |
BMC |
series |
Biology of Sex Differences |
issn |
2042-6410 |
publishDate |
2017-11-01 |
description |
Abstract Background Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate sex differences and stress effects on prefrontal cortical profiles of gene expression in squirrel monkey adults. Methods Dorsolateral, ventrolateral, and ventromedial prefrontal cortical regions from 18 females and 12 males were collected after stress or no-stress treatment conditions. Gene expression profiles were acquired using HumanHT-12v4.0 Expression BeadChip arrays adapted for squirrel monkeys. Results Extensive variation between prefrontal cortical regions was discerned in the expression of numerous autosomal and sex chromosome genes. Robust sex differences were also identified across prefrontal cortical regions in the expression of mostly autosomal genes. Genes with increased expression in females compared to males were overrepresented in mitogen-activated protein kinase and neurotrophin signaling pathways. Many fewer genes with increased expression in males compared to females were discerned, and no molecular pathways were identified. Effect sizes for sex differences were greater in stress compared to no-stress conditions for ventromedial and ventrolateral prefrontal cortical regions but not dorsolateral prefrontal cortex. Conclusions Stress amplifies sex differences in gene expression profiles for prefrontal cortical regions involved in stress coping and emotion regulation. Results suggest molecular targets for new treatments of stress disorders in human mental health. |
topic |
Social stress Sex biased Prefrontal cortex Gene expression profiling Neurotrophins MAPK signaling |
url |
http://link.springer.com/article/10.1186/s13293-017-0157-3 |
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