Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicar...

Full description

Bibliographic Details
Main Authors: Martin Kellert, Peter Lönnecke, Bernd Riedl, Johannes Koebberling, Evamarie Hey-Hawkins
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Molecules
Subjects:
boron neutron capture therapy
carborane
<i>s</i>-triazine
cancer therapy
modular system
Online Access:https://www.mdpi.com/1420-3049/24/18/3288
id doaj-8a23cb3fe6174af78dfad707c674edc2
record_format Article
spelling doaj-8a23cb3fe6174af78dfad707c674edc22020-11-25T02:01:12ZengMDPI AGMolecules1420-30492019-09-012418328810.3390/molecules24183288molecules24183288Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron LoadMartin Kellert0Peter Lönnecke1Bernd Riedl2Johannes Koebberling3Evamarie Hey-Hawkins4Institute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103 Leipzig, GermanyInstitute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103 Leipzig, GermanyBayer AG, Aprather Weg 18A, 42113 Wuppertal, GermanyBayer AG, Aprather Weg 18A, 42113 Wuppertal, GermanyInstitute of Inorganic Chemistry, Faculty of Chemistry and Mineralogy, Leipzig University, Johannisallee 29, 04103 Leipzig, GermanyThe amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-<i>closo</i>-dodecaborane(12), as well as &#945;-<span style="font-variant: small-caps;">d</span>-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-<i>meta</i>-carboranyl thiol.https://www.mdpi.com/1420-3049/24/18/3288boron neutron capture therapycarborane<i>s</i>-triazinecancer therapymodular system
collection DOAJ
language English
format Article
sources DOAJ
author Martin Kellert
Peter Lönnecke
Bernd Riedl
Johannes Koebberling
Evamarie Hey-Hawkins
spellingShingle Martin Kellert
Peter Lönnecke
Bernd Riedl
Johannes Koebberling
Evamarie Hey-Hawkins
Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
Molecules
boron neutron capture therapy
carborane
<i>s</i>-triazine
cancer therapy
modular system
author_facet Martin Kellert
Peter Lönnecke
Bernd Riedl
Johannes Koebberling
Evamarie Hey-Hawkins
author_sort Martin Kellert
title Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_short Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_full Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_fullStr Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_full_unstemmed Enlargement of a Modular System—Synthesis and Characterization of an <i>s</i>-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_sort enlargement of a modular system—synthesis and characterization of an <i>s</i>-triazine-based carboxylic acid ester bearing a galactopyranosyl moiety and an enormous boron load
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-09-01
description The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-<i>closo</i>-dodecaborane(12), as well as &#945;-<span style="font-variant: small-caps;">d</span>-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-<i>meta</i>-carboranyl thiol.
topic boron neutron capture therapy
carborane
<i>s</i>-triazine
cancer therapy
modular system
url https://www.mdpi.com/1420-3049/24/18/3288
work_keys_str_mv AT martinkellert enlargementofamodularsystemsynthesisandcharacterizationofanisitriazinebasedcarboxylicacidesterbearingagalactopyranosylmoietyandanenormousboronload
AT peterlonnecke enlargementofamodularsystemsynthesisandcharacterizationofanisitriazinebasedcarboxylicacidesterbearingagalactopyranosylmoietyandanenormousboronload
AT berndriedl enlargementofamodularsystemsynthesisandcharacterizationofanisitriazinebasedcarboxylicacidesterbearingagalactopyranosylmoietyandanenormousboronload
AT johanneskoebberling enlargementofamodularsystemsynthesisandcharacterizationofanisitriazinebasedcarboxylicacidesterbearingagalactopyranosylmoietyandanenormousboronload
AT evamarieheyhawkins enlargementofamodularsystemsynthesisandcharacterizationofanisitriazinebasedcarboxylicacidesterbearingagalactopyranosylmoietyandanenormousboronload
_version_ 1724958155277860864

Similar Items