Transcriptional effects of copy number alterations in a large set of human cancers
Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expressi...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14605-5 |
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Article |
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doaj-8a30eeb79fbb4839b329f70a9a9b46532021-05-11T09:09:18ZengNature Publishing GroupNature Communications2041-17232020-02-0111111210.1038/s41467-020-14605-5Transcriptional effects of copy number alterations in a large set of human cancersArkajyoti Bhattacharya0Rico D. Bense1Carlos G. Urzúa-Traslaviña2Elisabeth G. E. de Vries3Marcel A. T. M. van Vugt4Rudolf S. N. Fehrmann5Department of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenDepartment of Medical Oncology, University Medical Center Groningen, University of GroningenCopy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expression data without requiring paired CNA profiles.https://doi.org/10.1038/s41467-020-14605-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann |
| spellingShingle |
Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann Transcriptional effects of copy number alterations in a large set of human cancers Nature Communications |
| author_facet |
Arkajyoti Bhattacharya Rico D. Bense Carlos G. Urzúa-Traslaviña Elisabeth G. E. de Vries Marcel A. T. M. van Vugt Rudolf S. N. Fehrmann |
| author_sort |
Arkajyoti Bhattacharya |
| title |
Transcriptional effects of copy number alterations in a large set of human cancers |
| title_short |
Transcriptional effects of copy number alterations in a large set of human cancers |
| title_full |
Transcriptional effects of copy number alterations in a large set of human cancers |
| title_fullStr |
Transcriptional effects of copy number alterations in a large set of human cancers |
| title_full_unstemmed |
Transcriptional effects of copy number alterations in a large set of human cancers |
| title_sort |
transcriptional effects of copy number alterations in a large set of human cancers |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-02-01 |
| description |
Copy number alterations (CNAs) can drive tumor progression in cancer by altering gene expression levels, but transcriptional adaption can skew CNA impact. Here, the authors present transcriptional adaptation to CNA (TACNA) profiling; a tool to extract the transcriptional effect of CNAs from expression data without requiring paired CNA profiles. |
| url |
https://doi.org/10.1038/s41467-020-14605-5 |
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