Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study
Objective: It is known that patients with multiple sclerosis have a high incidence of headache. Although there is increasing evidence to suggest that periaqueductal gray matter (PAG) plays a role in the pathophysiology of migraine headache, it is not known whether the type of headache may be a pr...
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doaj-8a32f7b50b6c47be98cc73067926ede92021-09-02T06:31:44ZengModestum Publishing LTDJournal of Clinical and Experimental Investigations1309-85781309-66212018-03-019191310.5799/jcei.413052Headache in Multiple Sclerosis From a Different Perspective: A Prospective StudyGökhan Özer 0 Ufuk Ergün1 Levent Ertuğrul İnan2 Sanko University Faculty of Medicine, Department of Neurology, Gaziantep, TurkeyKırıkkale University School of Medicine, Kırıkkale, TurkeyBozok University School of Medicine, Yozgat, TurkeyObjective: It is known that patients with multiple sclerosis have a high incidence of headache. Although there is increasing evidence to suggest that periaqueductal gray matter (PAG) plays a role in the pathophysiology of migraine headache, it is not known whether the type of headache may be a predictor of a MS relapse. Patients and Methods: The study enrolled 100 patients (68 females, 32 males) with clinically confirmed MS diagnosis established by McDonald diagnostic criteria. The type and duration of MS, MRI localization of lesions and cognitive status were recorded for all patients. Patients were questioned whether they experience headache during MS attacks. Results: Sixty-eight percent of the patients had headache and 32% of the patients were free of headache. Of the patients with headache, 16% had tension –type headache (TTH), 14% had migraine, 11% had primary stabbing headache (PSH), 8% had TTH+ migraine, 6% had PSH+ migraine, 6% had medication overuse headache , 2% had medication overuse headache + migraine, 2% had paroxysmal hemicrania, 1% had cervicogenic headache, 1% had chronic TTH, and 1% had unclassified headache. There was a statistically significant relationship between the presence of headache and MS relapse (p<0.001). We found a statistically significant relationship between the type of headache and the localization of plaques in all MS patients in a statistical analysis using chi-square test, (p<0.001). Conclusion: Headache may be the only symptom of a flare-up in MS patients. The relationship between stabbing headache and MS relapses merits further investigation. http://jceionline.org/upload/sayi/40/JCEI-01442.pdfMultiple sclerosisrelapsestabbing headache |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gökhan Özer Ufuk Ergün Levent Ertuğrul İnan |
spellingShingle |
Gökhan Özer Ufuk Ergün Levent Ertuğrul İnan Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study Journal of Clinical and Experimental Investigations Multiple sclerosis relapse stabbing headache |
author_facet |
Gökhan Özer Ufuk Ergün Levent Ertuğrul İnan |
author_sort |
Gökhan Özer |
title |
Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study |
title_short |
Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study |
title_full |
Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study |
title_fullStr |
Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study |
title_full_unstemmed |
Headache in Multiple Sclerosis From a Different Perspective: A Prospective Study |
title_sort |
headache in multiple sclerosis from a different perspective: a prospective study |
publisher |
Modestum Publishing LTD |
series |
Journal of Clinical and Experimental Investigations |
issn |
1309-8578 1309-6621 |
publishDate |
2018-03-01 |
description |
Objective: It is known that patients with multiple sclerosis have a high incidence of headache.
Although there is increasing evidence to suggest that periaqueductal gray matter (PAG) plays
a role in the pathophysiology of migraine headache, it is not known whether the type of
headache may be a predictor of a MS relapse.
Patients and Methods: The study enrolled 100 patients (68 females, 32 males) with clinically
confirmed MS diagnosis established by McDonald diagnostic criteria. The type and duration of
MS, MRI localization of lesions and cognitive status were recorded for all patients. Patients were
questioned whether they experience headache during MS attacks.
Results: Sixty-eight percent of the patients had headache and 32% of the patients were free of
headache. Of the patients with headache, 16% had tension –type headache (TTH), 14% had
migraine, 11% had primary stabbing headache (PSH), 8% had TTH+ migraine, 6% had PSH+
migraine, 6% had medication overuse headache , 2% had medication overuse headache +
migraine, 2% had paroxysmal hemicrania, 1% had cervicogenic headache, 1% had chronic TTH,
and 1% had unclassified headache. There was a statistically significant relationship between the
presence of headache and MS relapse (p<0.001). We found a statistically significant relationship
between the type of headache and the localization of plaques in all MS patients in a statistical
analysis using chi-square test, (p<0.001).
Conclusion: Headache may be the only symptom of a flare-up in MS patients. The relationship
between stabbing headache and MS relapses merits further investigation.
|
topic |
Multiple sclerosis relapse stabbing headache |
url |
http://jceionline.org/upload/sayi/40/JCEI-01442.pdf |
work_keys_str_mv |
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