Fungal Culture Positivity in Patients with Perforation Peritonitis
Background: Perforation peritonitis is the most common surgical emergency. A large number of microorganisms have been cultured from the abdominal fluid obtained from patients with gastrointestinal perforation peritonitis. The present study was undertaken to determine the frequency of positive fu...
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doaj-8a37a390ab7c4d61b2ca5ca728ad22322020-11-25T03:04:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-06-0196DC01DC0310.7860/JCDR/2015/13189.6050Fungal Culture Positivity in Patients with Perforation PeritonitisNeerja Jindal0Shilpa Arora1Sumeet Pathania2Professor and Head, Department of Microbiology, GGS Medical College and Hospital, Faridkot, India.Assistant Professor, Department of Microbiology, GGS Medical College and Hospital, Faridkot, India.Junior Resident, Department of Surgery, GGS Medical College and Hospital, Faridkot, India.Background: Perforation peritonitis is the most common surgical emergency. A large number of microorganisms have been cultured from the abdominal fluid obtained from patients with gastrointestinal perforation peritonitis. The present study was undertaken to determine the frequency of positive fungal culture in perforation peritonitis as Candida co-infection is reported to be a bad prognostic factor in these patients. Materials and Methods: The intraoperative specimens of abdominal fluid collected during laparotomy from 140 consecutive patients of gastro-intestinal perforation were analysed by microbial culture for bacteria and fungi. Their antimicrobial susceptibility was also studied. Results: The mean presenting age of the patients was 35 years and 120 (85.7%) of them were males. Aerobic Gram Negative Bacilli (AGNB) were observed in 82 (79.6%) of the culture positive abdominal fluid specimens, of which 58 (70.7%) were Escherichia coli. Gram negative bacteria were most frequently isolated from colorectal perforation (100%) while Gram positive bacteria were from upper gastrointestinal perforation (47.2%). Candida was cultured in as many as 68 of 140 (48.6%) specimens. Its prevalence was highest in patients with gastroduodenal perforation (70.5%) and was altogether absent in patients having appendicular perforation. Conclusion: High prevalence of fungal culture positivity of peritoneal fluid of patients of perforation peritonitis shows that along with the bacterial culture, fungal cultures should always be asked for in such patients. Adequate and timely antimicrobial treatment including treatment of fungal infection could help reduce mortality in this group of patients. https://jcdr.net/articles/PDF/6050/13189_CE[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfcandidaintra-abdominal floraprognosissignificance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Neerja Jindal Shilpa Arora Sumeet Pathania |
spellingShingle |
Neerja Jindal Shilpa Arora Sumeet Pathania Fungal Culture Positivity in Patients with Perforation Peritonitis Journal of Clinical and Diagnostic Research candida intra-abdominal flora prognosis significance |
author_facet |
Neerja Jindal Shilpa Arora Sumeet Pathania |
author_sort |
Neerja Jindal |
title |
Fungal Culture Positivity in Patients with Perforation Peritonitis |
title_short |
Fungal Culture Positivity in Patients with Perforation Peritonitis |
title_full |
Fungal Culture Positivity in Patients with Perforation Peritonitis |
title_fullStr |
Fungal Culture Positivity in Patients with Perforation Peritonitis |
title_full_unstemmed |
Fungal Culture Positivity in Patients with Perforation Peritonitis |
title_sort |
fungal culture positivity in patients with perforation peritonitis |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2015-06-01 |
description |
Background: Perforation peritonitis is the most common
surgical emergency. A large number of microorganisms have
been cultured from the abdominal fluid obtained from patients
with gastrointestinal perforation peritonitis. The present study
was undertaken to determine the frequency of positive fungal
culture in perforation peritonitis as Candida co-infection is
reported to be a bad prognostic factor in these patients.
Materials and Methods: The intraoperative specimens
of abdominal fluid collected during laparotomy from 140
consecutive patients of gastro-intestinal perforation were
analysed by microbial culture for bacteria and fungi. Their
antimicrobial susceptibility was also studied.
Results: The mean presenting age of the patients was 35
years and 120 (85.7%) of them were males. Aerobic Gram
Negative Bacilli (AGNB) were observed in 82 (79.6%) of the
culture positive abdominal fluid specimens, of which 58
(70.7%) were Escherichia coli. Gram negative bacteria were
most frequently isolated from colorectal perforation (100%)
while Gram positive bacteria were from upper gastrointestinal
perforation (47.2%). Candida was cultured in as many as 68 of
140 (48.6%) specimens. Its prevalence was highest in patients
with gastroduodenal perforation (70.5%) and was altogether
absent in patients having appendicular perforation.
Conclusion: High prevalence of fungal culture positivity of
peritoneal fluid of patients of perforation peritonitis shows that
along with the bacterial culture, fungal cultures should always
be asked for in such patients. Adequate and timely antimicrobial
treatment including treatment of fungal infection could help
reduce mortality in this group of patients. |
topic |
candida intra-abdominal flora prognosis significance |
url |
https://jcdr.net/articles/PDF/6050/13189_CE[Ra]_F(P)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
work_keys_str_mv |
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