Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea
Different laboratory markers are routinely used in the diagnosis and management of gastrointestinal (GI) disease in dogs. In the present study, starting from feces from both healthy dogs and dogs suffering from food responsive diarrhea (FRD), we tried to find proteins differently expressed in the tw...
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doaj-8a39bf7765074e9db556980e9f928aa22020-11-24T22:15:02ZengHindawi LimitedThe Scientific World Journal2356-61401537-744X2019-01-01201910.1155/2019/27424012742401Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive DiarrheaMatteo Cerquetella0Giacomo Rossi1Andrea Spaterna2Beniamino Tesei3Alessandra Gavazza4Graziano Pengo5Stefania Pucciarelli6Luca Scortichini7Gianni Sagratini8Massimo Ricciutelli9Andrea Marchegiani10Silvia Vincenzetti11School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalyS. Antonio Clinic, Madignano, S.S 415 Paullese 6, 26020 Madignano (CR), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Pharmacy, University of Camerino, Via Sant'Agostino 1, 62032 Camerino (MC), ItalySchool of Pharmacy, University of Camerino, Via Sant'Agostino 1, 62032 Camerino (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione 93/95, 62024 Matelica (MC), ItalyDifferent laboratory markers are routinely used in the diagnosis and management of gastrointestinal (GI) disease in dogs. In the present study, starting from feces from both healthy dogs and dogs suffering from food responsive diarrhea (FRD), we tried to find proteins differently expressed in the two groups of dogs, by using a proteomic approach. Interestingly, we found that the immunoglobulin J-chain isoform 1 (species: Canis lupus familiaris) was identified only in diseased dogs (not in healthy). J-chain combines especially IgA monomers to IgA dimers and plays a crucial role for their secretions into mucosal interface. Being the first study of that kind in the dog, it is only possible to hypothesize that their presence could be likely due to an increased activation of the immune system or to a mucosal damage or both in FRD patients. Similarly, it is still impossible to assess whether this protein could be used as diagnostic/prognostic marker of GI disease; however, this study represents a promising first step toward fecal proteomics in canine GI disorders.http://dx.doi.org/10.1155/2019/2742401 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matteo Cerquetella Giacomo Rossi Andrea Spaterna Beniamino Tesei Alessandra Gavazza Graziano Pengo Stefania Pucciarelli Luca Scortichini Gianni Sagratini Massimo Ricciutelli Andrea Marchegiani Silvia Vincenzetti |
spellingShingle |
Matteo Cerquetella Giacomo Rossi Andrea Spaterna Beniamino Tesei Alessandra Gavazza Graziano Pengo Stefania Pucciarelli Luca Scortichini Gianni Sagratini Massimo Ricciutelli Andrea Marchegiani Silvia Vincenzetti Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea The Scientific World Journal |
author_facet |
Matteo Cerquetella Giacomo Rossi Andrea Spaterna Beniamino Tesei Alessandra Gavazza Graziano Pengo Stefania Pucciarelli Luca Scortichini Gianni Sagratini Massimo Ricciutelli Andrea Marchegiani Silvia Vincenzetti |
author_sort |
Matteo Cerquetella |
title |
Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea |
title_short |
Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea |
title_full |
Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea |
title_fullStr |
Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea |
title_full_unstemmed |
Fecal Proteomic Analysis in Healthy Dogs and in Dogs Suffering from Food Responsive Diarrhea |
title_sort |
fecal proteomic analysis in healthy dogs and in dogs suffering from food responsive diarrhea |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
2356-6140 1537-744X |
publishDate |
2019-01-01 |
description |
Different laboratory markers are routinely used in the diagnosis and management of gastrointestinal (GI) disease in dogs. In the present study, starting from feces from both healthy dogs and dogs suffering from food responsive diarrhea (FRD), we tried to find proteins differently expressed in the two groups of dogs, by using a proteomic approach. Interestingly, we found that the immunoglobulin J-chain isoform 1 (species: Canis lupus familiaris) was identified only in diseased dogs (not in healthy). J-chain combines especially IgA monomers to IgA dimers and plays a crucial role for their secretions into mucosal interface. Being the first study of that kind in the dog, it is only possible to hypothesize that their presence could be likely due to an increased activation of the immune system or to a mucosal damage or both in FRD patients. Similarly, it is still impossible to assess whether this protein could be used as diagnostic/prognostic marker of GI disease; however, this study represents a promising first step toward fecal proteomics in canine GI disorders. |
url |
http://dx.doi.org/10.1155/2019/2742401 |
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