Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths
Soil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children’s annual deworming. We aimed to characterize the immune profile of Honduran scho...
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doaj-8a45fd66e1b24b75a6afff92fe8b307a2020-11-24T23:18:43ZengHindawi LimitedJournal of Parasitology Research2090-00232090-00312016-01-01201610.1155/2016/17695851769585Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against GeohelminthsJosé Antonio Gabrie0María Mercedes Rueda1Carol Anahelka Rodríguez2Maritza Canales3Ana Lourdes Sanchez4Department of Health Sciences, Brock University, St. Catharines, ON, CanadaSchool of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, HondurasSchool of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, HondurasSchool of Microbiology, National Autonomous University of Honduras (UNAH), Tegucigalpa, HondurasDepartment of Health Sciences, Brock University, St. Catharines, ON, CanadaSoil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children’s annual deworming. We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses. Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels. A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study. Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively. Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions. Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN-γ ratios and decreased levels of IFN-γ). Pathogenic protozoa infections were associated with a Th1 response characterized by elevated levels of IFN-γ and decreased IL10/IFN-γ ratios. Even at low prevalence levels, STH infections affect children’s nutrition and play a polarizing role in their immune system.http://dx.doi.org/10.1155/2016/1769585 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Antonio Gabrie María Mercedes Rueda Carol Anahelka Rodríguez Maritza Canales Ana Lourdes Sanchez |
spellingShingle |
José Antonio Gabrie María Mercedes Rueda Carol Anahelka Rodríguez Maritza Canales Ana Lourdes Sanchez Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths Journal of Parasitology Research |
author_facet |
José Antonio Gabrie María Mercedes Rueda Carol Anahelka Rodríguez Maritza Canales Ana Lourdes Sanchez |
author_sort |
José Antonio Gabrie |
title |
Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths |
title_short |
Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths |
title_full |
Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths |
title_fullStr |
Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths |
title_full_unstemmed |
Immune Profile of Honduran Schoolchildren with Intestinal Parasites: The Skewed Response against Geohelminths |
title_sort |
immune profile of honduran schoolchildren with intestinal parasites: the skewed response against geohelminths |
publisher |
Hindawi Limited |
series |
Journal of Parasitology Research |
issn |
2090-0023 2090-0031 |
publishDate |
2016-01-01 |
description |
Soil-transmitted helminth infections typically induce a type-2 immune response (Th2), but no immunoepidemiological studies have been undertaken in Honduras, an endemic country where the main control strategy is children’s annual deworming. We aimed to characterize the immune profile of Honduran schoolchildren harbouring these parasitoses. Demographic and epidemiological data were obtained through a survey; nutritional status was assessed through anthropometry; intestinal parasites were diagnosed by formol-ether and Kato-Katz; and blood samples were collected to determine immunological markers including Th1/Th2 cytokines, IgE, and eosinophil levels. A total of 225 children participated in the study, all of whom had received deworming during the national campaign five months prior to the study. Trichuriasis and ascariasis prevalence were 22.2% and 20.4%, respectively. Stunting was associated with both age and trichuriasis, whereas ascariasis was associated with sex and household conditions. Helminth infections were strongly associated with eosinophilia and hyper-IgE as well as with a Th2-polarized response (increased levels of IL-13, IL-10, and IL4/IFN-γ ratios and decreased levels of IFN-γ). Pathogenic protozoa infections were associated with a Th1 response characterized by elevated levels of IFN-γ and decreased IL10/IFN-γ ratios. Even at low prevalence levels, STH infections affect children’s nutrition and play a polarizing role in their immune system. |
url |
http://dx.doi.org/10.1155/2016/1769585 |
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