Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art
Adipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval, and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem cells (ASCs) are indeed multipotent somatic...
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doaj-8a4e4f735a744388a2d0c8eded553b262020-11-24T21:02:53ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/416391416391Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the ArtMarta Barba0Claudia Cicione1Camilla Bernardini2Fabrizio Michetti3Wanda Lattanzi4Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyInstitute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168 Rome, ItalyAdipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval, and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem cells (ASCs) are indeed multipotent somatic stem cells exhibiting growth kinetics and plasticity, proved to induce efficient tissue regeneration in several biomedical applications. A defined consensus for their isolation, classification, and characterization has been very recently achieved. In particular, bone tissue reconstruction and regeneration based on ASCs has emerged as a promising approach to restore structure and function of bone compromised by injury or disease. ASCs have been used in combination with osteoinductive biomaterial and/or osteogenic molecules, in either static or dynamic culture systems, to improve bone regeneration in several animal models. To date, few clinical trials on ASC-based bone reconstruction have been concluded and proved effective. The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a comprehensive coverage of the topics, from the basic laboratory to recent clinical applications.http://dx.doi.org/10.1155/2013/416391 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marta Barba Claudia Cicione Camilla Bernardini Fabrizio Michetti Wanda Lattanzi |
spellingShingle |
Marta Barba Claudia Cicione Camilla Bernardini Fabrizio Michetti Wanda Lattanzi Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art BioMed Research International |
author_facet |
Marta Barba Claudia Cicione Camilla Bernardini Fabrizio Michetti Wanda Lattanzi |
author_sort |
Marta Barba |
title |
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art |
title_short |
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art |
title_full |
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art |
title_fullStr |
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art |
title_full_unstemmed |
Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art |
title_sort |
adipose-derived mesenchymal cells for bone regereneration: state of the art |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2013-01-01 |
description |
Adipose tissue represents a hot topic in regenerative medicine because of the tissue source abundance, the relatively easy retrieval, and the inherent biological properties of mesenchymal stem cells residing in its stroma. Adipose-derived mesenchymal stem cells (ASCs) are indeed multipotent somatic stem cells exhibiting growth kinetics and plasticity, proved to induce efficient tissue regeneration in several biomedical applications. A defined consensus for their isolation, classification, and characterization has been very recently achieved. In particular, bone tissue reconstruction and regeneration based on ASCs has emerged as a promising approach to restore structure and function of bone compromised by injury or disease. ASCs have been used in combination with osteoinductive biomaterial and/or osteogenic molecules, in either static or dynamic culture systems, to improve bone regeneration in several animal models. To date, few clinical trials on ASC-based bone reconstruction have been concluded and proved effective. The aim of this review is to dissect the state of the art on ASC use in bone regenerative applications in the attempt to provide a comprehensive coverage of the topics, from the basic laboratory to recent clinical applications. |
url |
http://dx.doi.org/10.1155/2013/416391 |
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