Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice

Background: It is well documented that elderly individuals are at increased risk of cognitive decline after anesthesia. General anesthesia is believed to be a risk factor for Alzheimer’s disease (AD). Recent studies suggest that anesthesia may increase the risk for cognitive decline and AD through...

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Bibliographic Details
Main Authors: Yanxing eChen, Xiaoqin eRun, Zhihou eLiang, Yang eZhao, CHUN-LING eDAI, Khalid eIqbal, Fei eLiu, CHENG-XIN eGONG
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Anesthesia
Propofol
Alzheimer’s disease
protein phosphatase 2a
brain insulin signaling
Intranasal insulin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00100/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00100/full

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