p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial Transcriptional States

p38 MAP Kinase Signaling in Microglia Plays a Sex-Specific Protective Role in CNS Autoimmunity and Regulates Microglial Transcriptional States

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system, representing the leading cause of non-traumatic neurologic disease in young adults. This disease is three times more common in women, yet more severe in men, but the mechanisms underlying these sex differen...

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Bibliographic Details
Main Authors: Mahalia M. McGill, Alyssa R. Richman, Joseph R. Boyd, Bristy Sabikunnahar, Karolyn G. Lahue, Theresa L. Montgomery, Sydney Caldwell, Stella Varnum, Seth Frietze, Dimitry N. Krementsov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
EAE (experimental autoimmune encephalomyelitis)
microglia
sex differences
MAPK
p38 alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.715311/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.715311/full

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