Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation. The faithful transmission of information through two-component pathways and the...

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Bibliographic Details
Main Authors:	Emily J Capra, Barrett S Perchuk, Emma A Lubin, Orr Ashenberg, Jeffrey M Skerker, Michael T Laub
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-11-01
Series:	PLoS Genetics
Online Access:	http://europepmc.org/articles/PMC2991266?pdf=render

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