Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer’s Disease

Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer’s Disease

The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that include rapamycin and caloric restriction (CR). In the central nervous system, mTOR inhibition dem...

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Bibliographic Details
Main Authors: Jennifer Lee, Lucille M. Yanckello, David Ma, Jared D. Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M. S. Hartz, Fahmeed Hyder, Ai-Ling Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
mechanistic target of rapamycin (mTOR)
rapamycin
caloric restriction
ketogentic diet
MRI
PET
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00225/full

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