Replication and Inhibitors of Enteroviruses and Parechoviruses
The Enterovirus (EV) and Parechovirus genera of the picornavirus family include many important human pathogens, including poliovirus, rhinovirus, EV-A71, EV-D68, and human parechoviruses (HPeV). They cause a wide variety of diseases, ranging from a simple common cold to life-threatening diseases suc...
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doaj-8a8279d67d244649811bc4654ca4dfb62020-11-24T22:35:00ZengMDPI AGViruses1999-49152015-08-01784529456210.3390/v7082832v7082832Replication and Inhibitors of Enteroviruses and ParechovirusesLonneke van der Linden0Katja C. Wolthers1Frank J.M. van Kuppeveld2Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The NetherlandsLaboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam 1105 AZ, The NetherlandsVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, Utrecht 3584 CL, The NetherlandsThe Enterovirus (EV) and Parechovirus genera of the picornavirus family include many important human pathogens, including poliovirus, rhinovirus, EV-A71, EV-D68, and human parechoviruses (HPeV). They cause a wide variety of diseases, ranging from a simple common cold to life-threatening diseases such as encephalitis and myocarditis. At the moment, no antiviral therapy is available against these viruses and it is not feasible to develop vaccines against all EVs and HPeVs due to the great number of serotypes. Therefore, a lot of effort is being invested in the development of antiviral drugs. Both viral proteins and host proteins essential for virus replication can be used as targets for virus inhibitors. As such, a good understanding of the complex process of virus replication is pivotal in the design of antiviral strategies goes hand in hand with a good understanding of the complex process of virus replication. In this review, we will give an overview of the current state of knowledge of EV and HPeV replication and how this can be inhibited by small-molecule inhibitors.http://www.mdpi.com/1999-4915/7/8/2832enterovirushuman parechovirusreplicationantiviralsmall moleculesinhibitor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lonneke van der Linden Katja C. Wolthers Frank J.M. van Kuppeveld |
spellingShingle |
Lonneke van der Linden Katja C. Wolthers Frank J.M. van Kuppeveld Replication and Inhibitors of Enteroviruses and Parechoviruses Viruses enterovirus human parechovirus replication antiviral small molecules inhibitor |
author_facet |
Lonneke van der Linden Katja C. Wolthers Frank J.M. van Kuppeveld |
author_sort |
Lonneke van der Linden |
title |
Replication and Inhibitors of Enteroviruses and Parechoviruses |
title_short |
Replication and Inhibitors of Enteroviruses and Parechoviruses |
title_full |
Replication and Inhibitors of Enteroviruses and Parechoviruses |
title_fullStr |
Replication and Inhibitors of Enteroviruses and Parechoviruses |
title_full_unstemmed |
Replication and Inhibitors of Enteroviruses and Parechoviruses |
title_sort |
replication and inhibitors of enteroviruses and parechoviruses |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2015-08-01 |
description |
The Enterovirus (EV) and Parechovirus genera of the picornavirus family include many important human pathogens, including poliovirus, rhinovirus, EV-A71, EV-D68, and human parechoviruses (HPeV). They cause a wide variety of diseases, ranging from a simple common cold to life-threatening diseases such as encephalitis and myocarditis. At the moment, no antiviral therapy is available against these viruses and it is not feasible to develop vaccines against all EVs and HPeVs due to the great number of serotypes. Therefore, a lot of effort is being invested in the development of antiviral drugs. Both viral proteins and host proteins essential for virus replication can be used as targets for virus inhibitors. As such, a good understanding of the complex process of virus replication is pivotal in the design of antiviral strategies goes hand in hand with a good understanding of the complex process of virus replication. In this review, we will give an overview of the current state of knowledge of EV and HPeV replication and how this can be inhibited by small-molecule inhibitors. |
topic |
enterovirus human parechovirus replication antiviral small molecules inhibitor |
url |
http://www.mdpi.com/1999-4915/7/8/2832 |
work_keys_str_mv |
AT lonnekevanderlinden replicationandinhibitorsofenterovirusesandparechoviruses AT katjacwolthers replicationandinhibitorsofenterovirusesandparechoviruses AT frankjmvankuppeveld replicationandinhibitorsofenterovirusesandparechoviruses |
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