Single institution experience of split course radiotherapy in patients with desmoid tumors
Jurui Luo,1,2,* Kairui Jin,1,2,* Shuizhang Qian,1,2 Xuejun Ma,1,2 Ziqiang Pan,1,2 Weiqiang Yao,1,2 Zhen Zhang,1,2 Xiaomao Guo,1,2 Xiaoli Yu1,2 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; 2Department of Oncology, Shanghai Medical College, Fudan...
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doaj-8a8316efaa2340e0a77f7d6ca7827a252020-11-24T23:07:41ZengDove Medical PressOncoTargets and Therapy1178-69302019-03-01Volume 121741174844490Single institution experience of split course radiotherapy in patients with desmoid tumorsLuo JJin KQian SMa XPan ZYao WZhang ZGuo XYu XJurui Luo,1,2,* Kairui Jin,1,2,* Shuizhang Qian,1,2 Xuejun Ma,1,2 Ziqiang Pan,1,2 Weiqiang Yao,1,2 Zhen Zhang,1,2 Xiaomao Guo,1,2 Xiaoli Yu1,2 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China *These authors contributed equally to this work Purpose: This study aimed to assess the feasibility of split course radiotherapy (SCRT) and reports long-term outcomes in patients with desmoid tumors (DT).Patients and methods: Between 2001 and 2004, 31 patients with recurrent (n=19) or primary large desmoid fibromatosis (≥10 cm) (n=12) who were treated with SCRT were retrospectively analyzed. All patients were treated with two phases of radiotherapy with a median interval time of 99 days (range: 81–122 days) and a median total dose of 6,399 cGy (range: 5,013–7,039 cGy). The median dose for the first phase was 3,969 cGy/22 Fx (range: 2,999–4,305 cGy), and 2,495 cGy/14 Fx (range: 1,982–3,039 cGy) for the second phase. Progression-free survival (PFS) in response to radiotherapy was evaluated using the Kaplan–Meier method and compared using the log-rank test. The prognostic factors associated with survival were evaluated by univariate and multivariate analyses.Results: The median age of all patients was 30 years (range, 7–58 years). With a median follow-up of 60.4 months (range, 2–187 months), eight patients experienced disease progression after treatment. The PFS rate at 3 and 5 years for the whole population was 90% and 71.3%, respectively. PFS for patients with split course of <100 days or ≥100 days interval was 100% vs 78.6% at 3 years, and 80.4% vs 62.9% at 5 years, respectively (P=0.189). In multivariate analysis, the radiotherapy (RT) interval time was an independent prognostic factor for PFS (≥100 days vs >100 days, HR 11.544, 95% CI 1.034–128.878, P=0.047). PFS was not significantly influenced by age, gender, surgery, tumor location, RT technology, or RT dose. Radiation-related acute complications occurred in nine (29%) patients after RT, and RT-related long-term complications occurred in three (9.7%) patients.Conclusion: SCRT with an appropriate treatment interval (<100 days) is well tolerated byDT patients with favorable long-term outcomes. Keywords: split course radiation, desmoid tumors, local control https://www.dovepress.com/single-institution-experience-of-split-course-radiotherapy-in-patients-peer-reviewed-article-OTTSplit course of radiotherapyDesmoid tumorsLocal control |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luo J Jin K Qian S Ma X Pan Z Yao W Zhang Z Guo X Yu X |
spellingShingle |
Luo J Jin K Qian S Ma X Pan Z Yao W Zhang Z Guo X Yu X Single institution experience of split course radiotherapy in patients with desmoid tumors OncoTargets and Therapy Split course of radiotherapy Desmoid tumors Local control |
author_facet |
Luo J Jin K Qian S Ma X Pan Z Yao W Zhang Z Guo X Yu X |
author_sort |
Luo J |
title |
Single institution experience of split course radiotherapy in patients with desmoid tumors |
title_short |
Single institution experience of split course radiotherapy in patients with desmoid tumors |
title_full |
Single institution experience of split course radiotherapy in patients with desmoid tumors |
title_fullStr |
Single institution experience of split course radiotherapy in patients with desmoid tumors |
title_full_unstemmed |
Single institution experience of split course radiotherapy in patients with desmoid tumors |
title_sort |
single institution experience of split course radiotherapy in patients with desmoid tumors |
publisher |
Dove Medical Press |
series |
OncoTargets and Therapy |
issn |
1178-6930 |
publishDate |
2019-03-01 |
description |
Jurui Luo,1,2,* Kairui Jin,1,2,* Shuizhang Qian,1,2 Xuejun Ma,1,2 Ziqiang Pan,1,2 Weiqiang Yao,1,2 Zhen Zhang,1,2 Xiaomao Guo,1,2 Xiaoli Yu1,2 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China *These authors contributed equally to this work Purpose: This study aimed to assess the feasibility of split course radiotherapy (SCRT) and reports long-term outcomes in patients with desmoid tumors (DT).Patients and methods: Between 2001 and 2004, 31 patients with recurrent (n=19) or primary large desmoid fibromatosis (≥10 cm) (n=12) who were treated with SCRT were retrospectively analyzed. All patients were treated with two phases of radiotherapy with a median interval time of 99 days (range: 81–122 days) and a median total dose of 6,399 cGy (range: 5,013–7,039 cGy). The median dose for the first phase was 3,969 cGy/22 Fx (range: 2,999–4,305 cGy), and 2,495 cGy/14 Fx (range: 1,982–3,039 cGy) for the second phase. Progression-free survival (PFS) in response to radiotherapy was evaluated using the Kaplan–Meier method and compared using the log-rank test. The prognostic factors associated with survival were evaluated by univariate and multivariate analyses.Results: The median age of all patients was 30 years (range, 7–58 years). With a median follow-up of 60.4 months (range, 2–187 months), eight patients experienced disease progression after treatment. The PFS rate at 3 and 5 years for the whole population was 90% and 71.3%, respectively. PFS for patients with split course of <100 days or ≥100 days interval was 100% vs 78.6% at 3 years, and 80.4% vs 62.9% at 5 years, respectively (P=0.189). In multivariate analysis, the radiotherapy (RT) interval time was an independent prognostic factor for PFS (≥100 days vs >100 days, HR 11.544, 95% CI 1.034–128.878, P=0.047). PFS was not significantly influenced by age, gender, surgery, tumor location, RT technology, or RT dose. Radiation-related acute complications occurred in nine (29%) patients after RT, and RT-related long-term complications occurred in three (9.7%) patients.Conclusion: SCRT with an appropriate treatment interval (<100 days) is well tolerated byDT patients with favorable long-term outcomes. Keywords: split course radiation, desmoid tumors, local control |
topic |
Split course of radiotherapy Desmoid tumors Local control |
url |
https://www.dovepress.com/single-institution-experience-of-split-course-radiotherapy-in-patients-peer-reviewed-article-OTT |
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