Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix
Nanoparticles facilitating sustained or controlled release of bioactive agents have been ubiquitously researched in many fields. The aim of this study was to tailor the release properties of folic acid encapsulated nanoparticles of alginate and pectin in gastrointestinal pHs, varying the matrix comp...
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doaj-8aa9c686191f4717be8ff200695aa6e32021-02-27T04:41:39ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392020-12-011100008Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrixGeethi Pamunuwa, Ph.D.0Nipunika Anjalee, B.Sc.1Diduli Kukulewa, B.Sc.2Chapa Edirisinghe, B.Sc.3Farrah Shakoor, B.Sc.4Desiree Nedra Karunaratne, Ph.D.5Department of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka; Corresponding author.Department of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri LankaDepartment of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri LankaDepartment of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri LankaDepartment of Horticulture and Landscape Gardening, Faculty of Agriculture and Plantation Management, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka; Postgraduate Institute of Science, University of Peradeniya, Peradeniya, Sri LankaDepartment of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri LankaNanoparticles facilitating sustained or controlled release of bioactive agents have been ubiquitously researched in many fields. The aim of this study was to tailor the release properties of folic acid encapsulated nanoparticles of alginate and pectin in gastrointestinal pHs, varying the matrix composition. The pectin content was increased up to 70%. The encapsulation efficiencies and loading capacities of the nanoparticles of size 200–400 nm varied from 44% to 92% and from 0.4% to 0.9%, respectively. The nanoparticles showed controlled release behavior with no/negligible release at pH 2. 100%-alginate nanoparticles exhibiting excellent release at pHs 6 and 7.4 showed first-order release behavior. A change in the release mechanism from non-Fickian anomalous release to non-Fickian case II release occurred with increasing pectin content. Briefly, tailoring the release kinetics and mechanisms of folic acid encapsulated nanoparticles by varying the alginate to pectin ratio may be exploited in designing nutraceuticals or functional foods.http://www.sciencedirect.com/science/article/pii/S2666893920300086AlginateFolic acidNanoparticlesPectinRelease kineticsRelease mechanisms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Geethi Pamunuwa, Ph.D. Nipunika Anjalee, B.Sc. Diduli Kukulewa, B.Sc. Chapa Edirisinghe, B.Sc. Farrah Shakoor, B.Sc. Desiree Nedra Karunaratne, Ph.D. |
spellingShingle |
Geethi Pamunuwa, Ph.D. Nipunika Anjalee, B.Sc. Diduli Kukulewa, B.Sc. Chapa Edirisinghe, B.Sc. Farrah Shakoor, B.Sc. Desiree Nedra Karunaratne, Ph.D. Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix Carbohydrate Polymer Technologies and Applications Alginate Folic acid Nanoparticles Pectin Release kinetics Release mechanisms |
author_facet |
Geethi Pamunuwa, Ph.D. Nipunika Anjalee, B.Sc. Diduli Kukulewa, B.Sc. Chapa Edirisinghe, B.Sc. Farrah Shakoor, B.Sc. Desiree Nedra Karunaratne, Ph.D. |
author_sort |
Geethi Pamunuwa, Ph.D. |
title |
Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
title_short |
Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
title_full |
Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
title_fullStr |
Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
title_full_unstemmed |
Tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
title_sort |
tailoring of release properties of folic acid encapsulated nanoparticles via changing alginate and pectin composition in the matrix |
publisher |
Elsevier |
series |
Carbohydrate Polymer Technologies and Applications |
issn |
2666-8939 |
publishDate |
2020-12-01 |
description |
Nanoparticles facilitating sustained or controlled release of bioactive agents have been ubiquitously researched in many fields. The aim of this study was to tailor the release properties of folic acid encapsulated nanoparticles of alginate and pectin in gastrointestinal pHs, varying the matrix composition. The pectin content was increased up to 70%. The encapsulation efficiencies and loading capacities of the nanoparticles of size 200–400 nm varied from 44% to 92% and from 0.4% to 0.9%, respectively. The nanoparticles showed controlled release behavior with no/negligible release at pH 2. 100%-alginate nanoparticles exhibiting excellent release at pHs 6 and 7.4 showed first-order release behavior. A change in the release mechanism from non-Fickian anomalous release to non-Fickian case II release occurred with increasing pectin content. Briefly, tailoring the release kinetics and mechanisms of folic acid encapsulated nanoparticles by varying the alginate to pectin ratio may be exploited in designing nutraceuticals or functional foods. |
topic |
Alginate Folic acid Nanoparticles Pectin Release kinetics Release mechanisms |
url |
http://www.sciencedirect.com/science/article/pii/S2666893920300086 |
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