Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs

Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs

The prevalence of low virulence classical swine fever virus (CSFV) strains makes viral eradication difficult in endemic countries. However, the determinants for natural CSFV attenuation and persistence in the field remain unidentified. The aim of the present study was to assess the role of the RNase...

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Bibliographic Details
Main Authors:	Miaomiao Wang, José Alejandro Bohórquez, Yoandry Hinojosa, Sara Muñoz-González, Markus Gerber, Liani Coronado, Carmen Laura Perera, Matthias Liniger, Nicolas Ruggli, Llilianne Ganges
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-01-01
Series:	Virulence
Subjects:	classical swine fever virus (csfv) erns rnase activity viral replication type i ifn viral attenuation viral persistence viral transmission humoral response pestivirus
Online Access:	http://dx.doi.org/10.1080/21505594.2021.1959715

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