An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia
Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and de...
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doaj-8ab86b3218824ed29ebd11cddc043ece2020-11-24T23:53:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-12-01810.3389/fnagi.2016.00276205939An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementiaGuo-qing Zheng0Hong-feng Zhang1Li-bo Huang2Yan-biao Zhong3Qi-hui Zhou4Hui-lin Wang5Yan Lin6The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical UniversityGinkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n=3), about vascular dementia (n=1), about both Alzheimer’s disease and vascular dementia (n=2), about Alzheimer’s disease, vascular dementia and mixed dementia (n=3), and a review about MCI (n=1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer's disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe.http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00276/fullDementiaGinkgo bilobaMild Cognitive ImpairmentAlzheimer’s diseaseVascular Dementia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guo-qing Zheng Hong-feng Zhang Li-bo Huang Yan-biao Zhong Qi-hui Zhou Hui-lin Wang Yan Lin |
spellingShingle |
Guo-qing Zheng Hong-feng Zhang Li-bo Huang Yan-biao Zhong Qi-hui Zhou Hui-lin Wang Yan Lin An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia Frontiers in Aging Neuroscience Dementia Ginkgo biloba Mild Cognitive Impairment Alzheimer’s disease Vascular Dementia |
author_facet |
Guo-qing Zheng Hong-feng Zhang Li-bo Huang Yan-biao Zhong Qi-hui Zhou Hui-lin Wang Yan Lin |
author_sort |
Guo-qing Zheng |
title |
An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
title_short |
An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
title_full |
An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
title_fullStr |
An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
title_full_unstemmed |
An overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
title_sort |
overview of systematic reviews of ginkgo biloba and its extracts for mild cognitive impairment and dementia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2016-12-01 |
description |
Ginkgo biloba extracts (GBEs) have been recommended to improve cognitive function and to prevent cognitive decline, but earlier evidence was inconclusive. Here, we evaluated all systematic reviews of GBEs for prevention of cognitive decline, and intervention of mild cognitive impairment (MCI) and dementia. Six databases from their inception to September 2015 were searched. Ten systematic reviews were identified, including reviews about Alzheimer’s disease (n=3), about vascular dementia (n=1), about both Alzheimer’s disease and vascular dementia (n=2), about Alzheimer’s disease, vascular dementia and mixed dementia (n=3), and a review about MCI (n=1). Based on the overview quality assessment questionnaire, eight studies were scored with at least 5 points, while the other two scored 4 points and 3 points, respectively. Medication with GBEs showed improvement in cognition, neuropsychiatric symptoms, and daily activities, and the effect was dose-dependent. Efficacy was convincingly demonstrated only when high daily dose (240mg) was applied. Compared with placebo, overall adverse events and serious adverse events were at the same level as placebo, with less adverse events in favor of GBE in the subgroup of Alzheimer's disease patients, and fewer incidences in vertigo, tinnitus, angina pectoris, and headache. In conclusion, there is clear evidence to support the efficacy of GBEs for MCI and dementia, whereas the question on efficacy to prevent cognitive decline is still open. In addition, GBEs seem to be generally safe. |
topic |
Dementia Ginkgo biloba Mild Cognitive Impairment Alzheimer’s disease Vascular Dementia |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00276/full |
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