Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible bi...
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Nature Publishing Group
2020-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15065-7 |
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doaj-8ab912eda75443699d2e15309d47801d2021-05-11T08:36:18ZengNature Publishing GroupNature Communications2041-17232020-03-0111111010.1038/s41467-020-15065-7Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s diseaseCostanza L. Vallerga0Futao Zhang1Javed Fowdar2Allan F. McRae3Ting Qi4Marta F. Nabais5Qian Zhang6Irfahan Kassam7Anjali K. Henders8Leanne Wallace9Grant Montgomery10Yu-Hsuan Chuang11Steve Horvath12Beate Ritz13Glenda Halliday14Ian Hickie15John B. Kwok16John Pearson17Toni Pitcher18Martin Kennedy19Steven R. Bentley20Peter A. Silburn21Jian Yang22Naomi R. Wray23Simon J. G. Lewis24Tim Anderson25John Dalrymple-Alford26George D. Mellick27Peter M. Visscher28Jacob Gratten29Institute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandGriffith Institute for Drug Discovery (GRIDD), Griffith UniversityInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandDepartment of Epidemiology, Fielding School of Public Health, UCLADepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles (UCLA)Department of Epidemiology, Fielding School of Public Health, UCLABrain and Mind Centre & Faculty of Medicine and Health, The University of SydneyBrain and Mind Centre & Faculty of Medicine and Health, The University of SydneyBrain and Mind Centre & Faculty of Medicine and Health, The University of SydneyDepartment of Pathology, University of OtagoNew Zealand Brain Research InstituteDepartment of Pathology, University of OtagoGriffith Institute for Drug Discovery (GRIDD), Griffith UniversityQueensland Brain Institute, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandBrain and Mind Centre & Faculty of Medicine and Health, The University of SydneyNew Zealand Brain Research InstituteNew Zealand Brain Research InstituteGriffith Institute for Drug Discovery (GRIDD), Griffith UniversityInstitute for Molecular Bioscience, The University of QueenslandInstitute for Molecular Bioscience, The University of QueenslandParkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target.https://doi.org/10.1038/s41467-020-15065-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten |
| spellingShingle |
Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease Nature Communications |
| author_facet |
Costanza L. Vallerga Futao Zhang Javed Fowdar Allan F. McRae Ting Qi Marta F. Nabais Qian Zhang Irfahan Kassam Anjali K. Henders Leanne Wallace Grant Montgomery Yu-Hsuan Chuang Steve Horvath Beate Ritz Glenda Halliday Ian Hickie John B. Kwok John Pearson Toni Pitcher Martin Kennedy Steven R. Bentley Peter A. Silburn Jian Yang Naomi R. Wray Simon J. G. Lewis Tim Anderson John Dalrymple-Alford George D. Mellick Peter M. Visscher Jacob Gratten |
| author_sort |
Costanza L. Vallerga |
| title |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_short |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_full |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_fullStr |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_full_unstemmed |
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease |
| title_sort |
analysis of dna methylation associates the cystine–glutamate antiporter slc7a11 with risk of parkinson’s disease |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-03-01 |
| description |
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target. |
| url |
https://doi.org/10.1038/s41467-020-15065-7 |
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