Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population
Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and it is more prevalent in Hispanic males. The gender differences can be explained by body fat distribution, lifestyle, or sex hormone metabolism. We evaluated anthropometric and meta...
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doaj-8abe6ec0223545cc9b81395f0efda1b62021-06-09T05:50:59ZengElsevierAnnals of Hepatology1665-26812019-09-01185693700Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric populationEréndira Villanueva-Ortega0María José Garcés-Hernández1Arturo Herrera-Rosas2Juan Carlos López-Alvarenga3Estibalitz Laresgoiti-Servitje4Galileo Escobedo5Gloria Queipo6Sergio Cuevas-Covarrubias7Guadalupe Nayely Garibay-Nieto8Pediatric Obesity Clinic, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico; School of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoSchool of Medicine, Universidad Nacional Autónoma de México, Mexico City, MexicoClinical Research Department, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoSchool of Medicine & South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX, USAClinical Medical Sciences, School of Medicine, Tecnológico de Monterrey, Campus Ciudad de México, Mexico City, MexicoExperimental Medicine Research Unit, Universidad Nacional Autónoma de México & Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoSchool of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico; Department of Human Genetics, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoDepartment of Human Genetics, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, MexicoPediatric Obesity Clinic, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico; School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico; Department of Human Genetics, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico; Corresponding author at: Department of Human Genetics, Hospital General de México “Dr Eduardo Liceaga”, Dr. Balmis 148, Col. Doctores, Delegación, Cuauhtémoc, CP 06720, Ciudad de México, Mexico.Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and it is more prevalent in Hispanic males. The gender differences can be explained by body fat distribution, lifestyle, or sex hormone metabolism. We evaluated anthropometric and metabolic differences by gender in children with and without NAFLD. Methods: We included 194 participants (eutrophic, overweight, and individuals with obesity). The presence of NAFLD was determined using ultrasonography, and we evaluated the association between this disease with metabolic and anthropometric variables by gender. Results: The mean age was 10.64 ± 2.54 years. The frequency of NAFLD in boys was 24.51% and in girls was 11.96% (OR = 2.39; 95%CI = 1.10–5.19; p = 0.025). For girls, NAFLD was significantly associated with triglycerides (p = 0.012), homeostatic model assessment of insulin resistance (HOMA-IR) (p = 0.048), and the visceral adiposity index (VAI) (p = 0.024). The variables related to NAFLD in a gender-specific manner were body mass index (BMI) (p = 0.001), waist circumference (WC) (p < 0.001), HDL cholesterol (p = 0.021), alanine aminotransferase (ALT) (p < 0.001), and aspartate aminotransferase (AST) (p = 0.002). Conclusions: In our study NAFLD is more frequent in boys, only ALT, and no other clinical or metabolic variables, were associated with NAFLD in these patients. HOMA-IR, VAI, triglyceride levels, and ALT were associated with NAFLD only in girls. The ALT cut-off points for the development of NAFLD in our study were 28.5 U/L in females and 27.5 U/L in males. Our findings showed that NAFLD should be intentionally screened in patients with obesity, particularly in boys.http://www.sciencedirect.com/science/article/pii/S1665268119303412NAFLDChildrenAdolescentsObesityGender |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eréndira Villanueva-Ortega María José Garcés-Hernández Arturo Herrera-Rosas Juan Carlos López-Alvarenga Estibalitz Laresgoiti-Servitje Galileo Escobedo Gloria Queipo Sergio Cuevas-Covarrubias Guadalupe Nayely Garibay-Nieto |
spellingShingle |
Eréndira Villanueva-Ortega María José Garcés-Hernández Arturo Herrera-Rosas Juan Carlos López-Alvarenga Estibalitz Laresgoiti-Servitje Galileo Escobedo Gloria Queipo Sergio Cuevas-Covarrubias Guadalupe Nayely Garibay-Nieto Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population Annals of Hepatology NAFLD Children Adolescents Obesity Gender |
author_facet |
Eréndira Villanueva-Ortega María José Garcés-Hernández Arturo Herrera-Rosas Juan Carlos López-Alvarenga Estibalitz Laresgoiti-Servitje Galileo Escobedo Gloria Queipo Sergio Cuevas-Covarrubias Guadalupe Nayely Garibay-Nieto |
author_sort |
Eréndira Villanueva-Ortega |
title |
Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population |
title_short |
Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population |
title_full |
Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population |
title_fullStr |
Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population |
title_full_unstemmed |
Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population |
title_sort |
gender-specific differences in clinical and metabolic variables associated with nafld in a mexican pediatric population |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2019-09-01 |
description |
Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and it is more prevalent in Hispanic males. The gender differences can be explained by body fat distribution, lifestyle, or sex hormone metabolism. We evaluated anthropometric and metabolic differences by gender in children with and without NAFLD. Methods: We included 194 participants (eutrophic, overweight, and individuals with obesity). The presence of NAFLD was determined using ultrasonography, and we evaluated the association between this disease with metabolic and anthropometric variables by gender. Results: The mean age was 10.64 ± 2.54 years. The frequency of NAFLD in boys was 24.51% and in girls was 11.96% (OR = 2.39; 95%CI = 1.10–5.19; p = 0.025). For girls, NAFLD was significantly associated with triglycerides (p = 0.012), homeostatic model assessment of insulin resistance (HOMA-IR) (p = 0.048), and the visceral adiposity index (VAI) (p = 0.024). The variables related to NAFLD in a gender-specific manner were body mass index (BMI) (p = 0.001), waist circumference (WC) (p < 0.001), HDL cholesterol (p = 0.021), alanine aminotransferase (ALT) (p < 0.001), and aspartate aminotransferase (AST) (p = 0.002). Conclusions: In our study NAFLD is more frequent in boys, only ALT, and no other clinical or metabolic variables, were associated with NAFLD in these patients. HOMA-IR, VAI, triglyceride levels, and ALT were associated with NAFLD only in girls. The ALT cut-off points for the development of NAFLD in our study were 28.5 U/L in females and 27.5 U/L in males. Our findings showed that NAFLD should be intentionally screened in patients with obesity, particularly in boys. |
topic |
NAFLD Children Adolescents Obesity Gender |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119303412 |
work_keys_str_mv |
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