Transition metal-catalysed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties

Transition metal-catalysed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-oestrone series and in vitro evaluation of antiproliferative properties

Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13α-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki–Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13α-oestrone d...

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Bibliographic Details
Main Authors: Péter Traj, Ali Hazhmat Abdolkhaliq, Anett Németh, Sámuel Trisztán Dajcs, Ferenc Tömösi, Tea Lanisnik-Rizner, István Zupkó, Erzsébet Mernyák
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
13α-oestrone
c‒h activation
suzuki–miyaura coupling
human reproductive cell lines
antiproliferative action
Online Access:http://dx.doi.org/10.1080/14756366.2021.1900165

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