Notch Signaling in Pancreatic Development
The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor...
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doaj-8ac9f6d3f36240a09196b4d50b2159832020-11-24T22:15:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-12-011714810.3390/ijms17010048ijms17010048Notch Signaling in Pancreatic DevelopmentXu-Yan Li0Wen-Jun Zhai1Chun-Bo Teng2College of Life Science, Northeast Forestry University, Harbin 150040, ChinaCollege of Life Science, Northeast Forestry University, Harbin 150040, ChinaCollege of Life Science, Northeast Forestry University, Harbin 150040, ChinaThe Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways.http://www.mdpi.com/1422-0067/17/1/48pancreatic progenitorNotch signalingdifferentiationmaintenance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xu-Yan Li Wen-Jun Zhai Chun-Bo Teng |
spellingShingle |
Xu-Yan Li Wen-Jun Zhai Chun-Bo Teng Notch Signaling in Pancreatic Development International Journal of Molecular Sciences pancreatic progenitor Notch signaling differentiation maintenance |
author_facet |
Xu-Yan Li Wen-Jun Zhai Chun-Bo Teng |
author_sort |
Xu-Yan Li |
title |
Notch Signaling in Pancreatic Development |
title_short |
Notch Signaling in Pancreatic Development |
title_full |
Notch Signaling in Pancreatic Development |
title_fullStr |
Notch Signaling in Pancreatic Development |
title_full_unstemmed |
Notch Signaling in Pancreatic Development |
title_sort |
notch signaling in pancreatic development |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2015-12-01 |
description |
The Notch signaling pathway plays a significant role in embryonic cell fate determination and adult tissue homeostasis. Various studies have demonstrated the deep involvement of Notch signaling in the development of the pancreas and the lateral inhibition of Notch signaling in pancreatic progenitor differentiation and maintenance. The targeted inactivation of the Notch pathway components promotes premature differentiation of the endocrine pancreas. However, there is still the contrary opinion that Notch signaling specifies the endocrine lineage. Here, we review the current knowledge of the Notch signaling pathway in pancreatic development and its crosstalk with the Wingless and INT-1 (Wnt) and fibroblast growth factor (FGF) pathways. |
topic |
pancreatic progenitor Notch signaling differentiation maintenance |
url |
http://www.mdpi.com/1422-0067/17/1/48 |
work_keys_str_mv |
AT xuyanli notchsignalinginpancreaticdevelopment AT wenjunzhai notchsignalinginpancreaticdevelopment AT chunboteng notchsignalinginpancreaticdevelopment |
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1725791934443683840 |