Evaluation of the neurotoxical effect of aluminum on the Wistar rat

• Main Authors: Martać L., Podgorac J., Sekulić S.
• Format: Article
• Language: English
• Published: University of Belgrade, University of Novi Sad 2010-01-01
• Series: Archives of Biological Sciences
• Subjects: aluminum; neurotoxicity; Wistar rats
• Online Access: http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003585M.pdf

Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease. .