MafB is a critical regulator of complement component C1q
Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01711-0 |
| id |
doaj-8ad6548fe15640be8a3fcc672a1b03f2 |
|---|---|
| record_format |
Article |
| spelling |
doaj-8ad6548fe15640be8a3fcc672a1b03f22021-05-11T07:44:41ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-01711-0MafB is a critical regulator of complement component C1qMai Thi Nhu Tran0Michito Hamada1Hyojung Jeon2Risako Shiraishi3Keigo Asano4Motochika Hattori5Megumi Nakamura6Yuki Imamura7Yuki Tsunakawa8Risa Fujii9Toshiaki Usui10Kaushalya Kulathunga11Christina-Sylvia Andrea12Ryusuke Koshida13Risa Kamei14Yurina Matsunaga15Makoto Kobayashi16Hisashi Oishi17Takashi Kudo18Satoru Takahashi19Department of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Molecular and Developmental Biology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Molecular and Developmental Biology, Faculty of Medicine, University of TsukubaDepartment of Comparative and Experimental Medicine, Nagoya City University Graduate 24 School of Medical SciencesDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaDepartment of Anatomy and Embryology, Faculty of Medicine, University of TsukubaComplement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.https://doi.org/10.1038/s41467-017-01711-0 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi |
| spellingShingle |
Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi MafB is a critical regulator of complement component C1q Nature Communications |
| author_facet |
Mai Thi Nhu Tran Michito Hamada Hyojung Jeon Risako Shiraishi Keigo Asano Motochika Hattori Megumi Nakamura Yuki Imamura Yuki Tsunakawa Risa Fujii Toshiaki Usui Kaushalya Kulathunga Christina-Sylvia Andrea Ryusuke Koshida Risa Kamei Yurina Matsunaga Makoto Kobayashi Hisashi Oishi Takashi Kudo Satoru Takahashi |
| author_sort |
Mai Thi Nhu Tran |
| title |
MafB is a critical regulator of complement component C1q |
| title_short |
MafB is a critical regulator of complement component C1q |
| title_full |
MafB is a critical regulator of complement component C1q |
| title_fullStr |
MafB is a critical regulator of complement component C1q |
| title_full_unstemmed |
MafB is a critical regulator of complement component C1q |
| title_sort |
mafb is a critical regulator of complement component c1q |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-11-01 |
| description |
Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice. |
| url |
https://doi.org/10.1038/s41467-017-01711-0 |
| work_keys_str_mv |
AT maithinhutran mafbisacriticalregulatorofcomplementcomponentc1q AT michitohamada mafbisacriticalregulatorofcomplementcomponentc1q AT hyojungjeon mafbisacriticalregulatorofcomplementcomponentc1q AT risakoshiraishi mafbisacriticalregulatorofcomplementcomponentc1q AT keigoasano mafbisacriticalregulatorofcomplementcomponentc1q AT motochikahattori mafbisacriticalregulatorofcomplementcomponentc1q AT meguminakamura mafbisacriticalregulatorofcomplementcomponentc1q AT yukiimamura mafbisacriticalregulatorofcomplementcomponentc1q AT yukitsunakawa mafbisacriticalregulatorofcomplementcomponentc1q AT risafujii mafbisacriticalregulatorofcomplementcomponentc1q AT toshiakiusui mafbisacriticalregulatorofcomplementcomponentc1q AT kaushalyakulathunga mafbisacriticalregulatorofcomplementcomponentc1q AT christinasylviaandrea mafbisacriticalregulatorofcomplementcomponentc1q AT ryusukekoshida mafbisacriticalregulatorofcomplementcomponentc1q AT risakamei mafbisacriticalregulatorofcomplementcomponentc1q AT yurinamatsunaga mafbisacriticalregulatorofcomplementcomponentc1q AT makotokobayashi mafbisacriticalregulatorofcomplementcomponentc1q AT hisashioishi mafbisacriticalregulatorofcomplementcomponentc1q AT takashikudo mafbisacriticalregulatorofcomplementcomponentc1q AT satorutakahashi mafbisacriticalregulatorofcomplementcomponentc1q |
| _version_ |
1721451657277997056 |