Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs

Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an ove...

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Main Authors:	Anna Karagianni, Maria Malamatari, Kyriakos Kachrimanis
Format:	Article
Language:	English
Published:	MDPI AG 2018-01-01
Series:	Pharmaceutics
Subjects:	cocrystals coformers solid state properties poorly soluble APIs
Online Access:	http://www.mdpi.com/1999-4923/10/1/18

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spelling	doaj-8aee6cd0549c4ab3bb8e58fe91ef3e4e2020-11-24T20:45:32ZengMDPI AGPharmaceutics1999-49232018-01-011011810.3390/pharmaceutics10010018pharmaceutics10010018Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIsAnna Karagianni0Maria Malamatari1Kyriakos Kachrimanis2Department of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54351 Thessaloniki, GreeceFaculty of Engineering and Science, University of Greenwich at Medway, Kent ME4 4TB, UKDepartment of Pharmaceutical Technology, Aristotle University of Thessaloniki, 54351 Thessaloniki, GreeceCocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development.http://www.mdpi.com/1999-4923/10/1/18cocrystalscoformerssolid state propertiespoorly soluble APIs
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anna Karagianni Maria Malamatari Kyriakos Kachrimanis
spellingShingle	Anna Karagianni Maria Malamatari Kyriakos Kachrimanis Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs Pharmaceutics cocrystals coformers solid state properties poorly soluble APIs
author_facet	Anna Karagianni Maria Malamatari Kyriakos Kachrimanis
author_sort	Anna Karagianni
title	Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
title_short	Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
title_full	Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
title_fullStr	Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
title_full_unstemmed	Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs
title_sort	pharmaceutical cocrystals: new solid phase modification approaches for the formulation of apis
publisher	MDPI AG
series	Pharmaceutics
issn	1999-4923
publishDate	2018-01-01
description	Cocrystals can be used as an alternative approach based on crystal engineering to enhance specific physicochemical and biopharmaceutical properties of active pharmaceutical ingredients (APIs) when the approaches to salt or polymorph formation do not meet the expected targets. In this article, an overview of pharmaceutical cocrystals will be presented, with an emphasis on the intermolecular interactions in cocrystals and the methods for their preparation. Furthermore, cocrystals of direct pharmaceutical interest, along with their in vitro properties and available in vivo data and characterization techniques are discussed, highlighting the potential of cocrystals as an attractive route for drug development.
topic	cocrystals coformers solid state properties poorly soluble APIs
url	http://www.mdpi.com/1999-4923/10/1/18
work_keys_str_mv	AT annakaragianni pharmaceuticalcocrystalsnewsolidphasemodificationapproachesfortheformulationofapis AT mariamalamatari pharmaceuticalcocrystalsnewsolidphasemodificationapproachesfortheformulationofapis AT kyriakoskachrimanis pharmaceuticalcocrystalsnewsolidphasemodificationapproachesfortheformulationofapis
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Pharmaceutical Cocrystals: New Solid Phase Modification Approaches for the Formulation of APIs

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