The short-term effects of Helicobacter pylori eradication on symptoms of functional dyspepsia

• Main Authors: Ayla Tezer, Oktay Bulur, Mehmet Yıldız, Abdullah Özgür Yeniova, Yaşar Nazlıgül, Esen Ağbaba, Heyacan Ökten
• Format: Article
• Language: English
• Published: Dicle University Medical School 2010-09-01
• Series: Dicle Medical Journal
• Subjects: Helicobacter pylori; eradication; functional dyspepsia
• Online Access: http://www.dicle.edu.tr/fakulte/tip/dergi/yayin/373/04.pdf
• ISSN: 1300-2945; 1308-9889

Objectives: Helicobacter pylori (H.pylori) infection is major etiologic factor of chronic active gastritis and peptic ulcer disease. Functional dyspepsia (FD) is defined as “persistent or recurrent abdominal pain or discomfort centered in the upper abdomen in patient who has no definite structural or biochemical explanation of their symptoms. It is uncertain whether treatment of H.pylori infection relieves symptoms in patients with FD. We searched short term effects of H.pylori eradication for symptoms in patients with FD.Material and method: We enrolled patients with dyspeptic symptoms which were diagnosed FD and satisfied en-rollment criteria of trial. Endoscopic biopsy was taken from each patient during upper gastrointestinal endoscopy. H.pylori infected patients were assigned to seven days of treatment with 30 mgr of lansoprozole twice daily, 1000 mg of amoksisilin twice daily, and 500 mg levofloxacin once daily. Patients were assessed whether treatment was suc-cessful or not by 14C urea breathe test after 6-8 week. Also pretreatment and post treatment symptom scores were questioned.Results: There were 99 female and 68 male patients. After treatment 114 patients (68%) was negative for H. pylori, 53 patients (32%) remained positive. Mean of age and proportion of sex was similar in H.pylori (+) and (-) groups. While 111 (97.4%) of H.pylori (-) patients’ symptom scores decreased, 38 (71.7%) of H.pylori (+) patients’ scores de-creased. There was significant differences between two groups (p=0.001).Conclusion: Eradication of H.pylori relieves the symptoms of functional dyspepsia. New trials for long term effect of H.pylori eradication on symptoms must be conducted in future.