Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis
Background: The prevalence of hypothyroidism in persons with chronic kidney disease is documented to be higher, compared to the normal population. However, no data is available about the prevalence rate of hypothyroidism among hemodialysis patients in Nepal. Methods: A cross-sectional analysis...
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doaj-8af3b0ae19fc46bea8ba79d9c02ebc752020-11-25T02:54:36ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-04-0184MC01MC0410.7860/JCDR/2014/7821.4246Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance HemodialysisKlara Paudel0Clinical Fellow in Nephrology, Department of Renal Medicine and Transplantation, Barts Health NHS Trust, London, UK.Background: The prevalence of hypothyroidism in persons with chronic kidney disease is documented to be higher, compared to the normal population. However, no data is available about the prevalence rate of hypothyroidism among hemodialysis patients in Nepal. Methods: A cross-sectional analysis was done on consecutive patients enrolled for maintenance hemodialysis in the Hemodialysis Unit of Gandaki Medical College Teaching Hospital, Pokhara, Nepal, during the period of one year (1st January 2011 to 31st December 2011). Total 64 subjects with end stage renal disease were recruited for the study. Thyroid function tests were performed at the time of starting regular hemodialysis. Classical symptoms and signs of hypothyroidism were assessed in all patients. Results: Among the study subjects 17 (26.6%) had serum thyroid stimulating hormone levels above the laboratory reference range (>6.16 µIU/mL). Among them 12 (18.7%) patients had clinically significant symptoms or signs requiring thyroxin replacement. Cold intolerance, constipation, tingling sensation, dry skin, periorbital odema, pericardial effusion, pleural effusion and ascites were found at significantly higher rate in the hypothyroid patient group (p<0.05). Conclusion: The diagnosis of hypothyroidism can be easily missed in the end-stage kidney disease population, because the symptoms of chronic kidney disease and hypothyroidism overlap. In our study we have found high prevalence of hypothyroidism. Clinicians should pay attention on this factor and screen routinely for thyroid disorders in the chronic kidney disease population.https://jcdr.net/articles/PDF/4246/7821_E(C)_F(T)_PF1(PAK)_PFA(NC_P)_PF2(PN).pdfchronic kidney diseasethyroid disordernepal |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Klara Paudel |
spellingShingle |
Klara Paudel Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis Journal of Clinical and Diagnostic Research chronic kidney disease thyroid disorder nepal |
author_facet |
Klara Paudel |
author_sort |
Klara Paudel |
title |
Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis |
title_short |
Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis |
title_full |
Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis |
title_fullStr |
Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis |
title_full_unstemmed |
Prevalence and Clinical Characteristics of Hypothyroidism in a Population Undergoing Maintenance Hemodialysis |
title_sort |
prevalence and clinical characteristics of hypothyroidism in a population undergoing maintenance hemodialysis |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2014-04-01 |
description |
Background: The prevalence of hypothyroidism in persons with
chronic kidney disease is documented to be higher, compared to
the normal population. However, no data is available about the
prevalence rate of hypothyroidism among hemodialysis patients
in Nepal.
Methods: A cross-sectional analysis was done on consecutive
patients enrolled for maintenance hemodialysis in the
Hemodialysis Unit of Gandaki Medical College Teaching Hospital,
Pokhara, Nepal, during the period of one year (1st January 2011
to 31st December 2011). Total 64 subjects with end stage renal
disease were recruited for the study. Thyroid function tests were
performed at the time of starting regular hemodialysis. Classical
symptoms and signs of hypothyroidism were assessed in all
patients.
Results: Among the study subjects 17 (26.6%) had serum thyroid
stimulating hormone levels above the laboratory reference range
(>6.16 µIU/mL). Among them 12 (18.7%) patients had clinically
significant symptoms or signs requiring thyroxin replacement.
Cold intolerance, constipation, tingling sensation, dry skin,
periorbital odema, pericardial effusion, pleural effusion and
ascites were found at significantly higher rate in the hypothyroid
patient group (p<0.05).
Conclusion: The diagnosis of hypothyroidism can be easily
missed in the end-stage kidney disease population, because the
symptoms of chronic kidney disease and hypothyroidism overlap.
In our study we have found high prevalence of hypothyroidism.
Clinicians should pay attention on this factor and screen routinely
for thyroid disorders in the chronic kidney disease population. |
topic |
chronic kidney disease thyroid disorder nepal |
url |
https://jcdr.net/articles/PDF/4246/7821_E(C)_F(T)_PF1(PAK)_PFA(NC_P)_PF2(PN).pdf |
work_keys_str_mv |
AT klarapaudel prevalenceandclinicalcharacteristicsofhypothyroidisminapopulationundergoingmaintenancehemodialysis |
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