NK cells during dengue disease and their recognition of dengue virus-infected cells
The innate immune response, in addition to the B and T cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of NK cells and type-I interferon-dependent immunity may be important in limiting viral replication during the e...
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doaj-8b0791a893dc45c2803f0504d36b0ef22020-11-24T21:23:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-05-01510.3389/fimmu.2014.0019287592NK cells during dengue disease and their recognition of dengue virus-infected cellsDavis Alexander Beltrán0Davis Alexander Beltrán1Davis Alexander Beltrán2Sandra Laurence Lopez-Verges3Gorgas Memorial Institute for Health StudiesAcharya Nagarjuna UniversityINDICASAT-AIPGorgas Memorial Institute for Health StudiesThe innate immune response, in addition to the B and T cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of NK cells and type-I interferon-dependent immunity may be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENV-infected cells through antibody-dependent cell-mediated cytotoxicity (ADCC). In additional, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies (GWAS) have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome. This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00192/fullDengueNK receptorinnate immune responseNK cellNK ligand |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Davis Alexander Beltrán Davis Alexander Beltrán Davis Alexander Beltrán Sandra Laurence Lopez-Verges |
spellingShingle |
Davis Alexander Beltrán Davis Alexander Beltrán Davis Alexander Beltrán Sandra Laurence Lopez-Verges NK cells during dengue disease and their recognition of dengue virus-infected cells Frontiers in Immunology Dengue NK receptor innate immune response NK cell NK ligand |
author_facet |
Davis Alexander Beltrán Davis Alexander Beltrán Davis Alexander Beltrán Sandra Laurence Lopez-Verges |
author_sort |
Davis Alexander Beltrán |
title |
NK cells during dengue disease and their recognition of dengue virus-infected cells |
title_short |
NK cells during dengue disease and their recognition of dengue virus-infected cells |
title_full |
NK cells during dengue disease and their recognition of dengue virus-infected cells |
title_fullStr |
NK cells during dengue disease and their recognition of dengue virus-infected cells |
title_full_unstemmed |
NK cells during dengue disease and their recognition of dengue virus-infected cells |
title_sort |
nk cells during dengue disease and their recognition of dengue virus-infected cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2014-05-01 |
description |
The innate immune response, in addition to the B and T cell response, plays a role in protection against dengue virus (DENV) infection and the degree of disease severity. Early activation of NK cells and type-I interferon-dependent immunity may be important in limiting viral replication during the early stages of DENV infection and thus reducing subsequent pathogenesis. NK cells may also produce cytokines that reduce inflammation and tissue injury. On the other hand, NK cells are also capable of inducing liver injury at early-time points of DENV infection. In vitro, NK cells can kill antibody-coated DENV-infected cells through antibody-dependent cell-mediated cytotoxicity (ADCC). In additional, NK cells may directly recognize DENV-infected cells through their activating receptors, although the increase in HLA class I expression may allow infected cells to escape the NK response. Recently, genome-wide association studies (GWAS) have shown an association between MICB and MICA, which encode ligands of the activating NK receptor NKG2D, and dengue disease outcome. This review focuses on recognition of DENV-infected cells by NK cells and on the regulation of expression of NK cell ligands by DENV. |
topic |
Dengue NK receptor innate immune response NK cell NK ligand |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00192/full |
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