A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana

A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana

Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA...

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Main Authors: Chalé-balboa W.G., Mut-Martin M., Ramirez-Sierra M.J., Garcia-Miss M.R., Dumonteil E.
Format: Article
Language:English
Published: EDP Sciences 2009-09-01
Series:Parasite
Subjects:
leishmaniasis
vaccine
hamster
Online Access:http://dx.doi.org/10.1051/parasite/2009163227
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spelling doaj-8b30485b918947699b365c20afcbf4ea2021-02-02T02:28:07ZengEDP SciencesParasite1252-607X1776-10422009-09-0116322723010.1051/parasite/2009163227parasite2009163p227A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicanaChalé-balboa W.G.Mut-Martin M.Ramirez-Sierra M.J.Garcia-Miss M.R.Dumonteil E.Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions.http://dx.doi.org/10.1051/parasite/2009163227leishmaniasisvaccinehamster
collection DOAJ
language English
format Article
sources DOAJ
author Chalé-balboa W.G.
Mut-Martin M.
Ramirez-Sierra M.J.
Garcia-Miss M.R.
Dumonteil E.
spellingShingle Chalé-balboa W.G.
Mut-Martin M.
Ramirez-Sierra M.J.
Garcia-Miss M.R.
Dumonteil E.
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
Parasite
leishmaniasis
vaccine
hamster
author_facet Chalé-balboa W.G.
Mut-Martin M.
Ramirez-Sierra M.J.
Garcia-Miss M.R.
Dumonteil E.
author_sort Chalé-balboa W.G.
title A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
title_short A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
title_full A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
title_fullStr A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
title_full_unstemmed A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
title_sort combination dna vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against leishmania mexicana
publisher EDP Sciences
series Parasite
issn 1252-607X
1776-1042
publishDate 2009-09-01
description Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions.
topic leishmaniasis
vaccine
hamster
url http://dx.doi.org/10.1051/parasite/2009163227
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