A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana
Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA...
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2009-09-01
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Online Access: | http://dx.doi.org/10.1051/parasite/2009163227 |
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doaj-8b30485b918947699b365c20afcbf4ea2021-02-02T02:28:07ZengEDP SciencesParasite1252-607X1776-10422009-09-0116322723010.1051/parasite/2009163227parasite2009163p227A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicanaChalé-balboa W.G.Mut-Martin M.Ramirez-Sierra M.J.Garcia-Miss M.R.Dumonteil E.Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions.http://dx.doi.org/10.1051/parasite/2009163227leishmaniasisvaccinehamster |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chalé-balboa W.G. Mut-Martin M. Ramirez-Sierra M.J. Garcia-Miss M.R. Dumonteil E. |
spellingShingle |
Chalé-balboa W.G. Mut-Martin M. Ramirez-Sierra M.J. Garcia-Miss M.R. Dumonteil E. A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana Parasite leishmaniasis vaccine hamster |
author_facet |
Chalé-balboa W.G. Mut-Martin M. Ramirez-Sierra M.J. Garcia-Miss M.R. Dumonteil E. |
author_sort |
Chalé-balboa W.G. |
title |
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana |
title_short |
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana |
title_full |
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana |
title_fullStr |
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana |
title_full_unstemmed |
A combination DNA vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against Leishmania mexicana |
title_sort |
combination dna vaccine encoding nucleoside hydrolase 36 and glycoproteine 63 protects female but not male hamsters against leishmania mexicana |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1252-607X 1776-1042 |
publishDate |
2009-09-01 |
description |
Leishmaniasis is a group of diseases caused by protozoan parasites of the Leishmania genus. Previous studies have shown that a DNA vaccine encoding Leishmania donovani antigen nucleoside hydrolase 36 and L. mexicana glycoprotein 63 is protective in mice. We investigated here the efficacy of this DNA vaccine to induce protection in golden hamsters. Male hamsters were more susceptible to infection by Leishmania mexicana than females. Following immunization with two doses of the DNA vaccine, only females resulted protected while males developed normal lesions. |
topic |
leishmaniasis vaccine hamster |
url |
http://dx.doi.org/10.1051/parasite/2009163227 |
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