Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.
The nitric oxide (NO)/soluble guanylate cyclase (sGC)/cyclic guanosine monophasphate (cGMP)-signalling pathway is impaired under oxidative stress conditions due to oxidation and subsequent loss of the prosthetic sGC heme group as observed in particular in chronic renal failure. Thus, the pool of hem...
Main Authors: | Linda S Hoffmann, Axel Kretschmer, Bettina Lawrenz, Berthold Hocher, Johannes-Peter Stasch |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4700984?pdf=render |
Similar Items
-
Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats.
by: Sandra Geschka, et al.
Published: (2011-01-01) -
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.
by: Linda S Hoffmann, et al.
Published: (2011-01-01) -
Effects of stimulation of soluble guanylate cyclase on diabetic nephropathy in diabetic eNOS knockout mice on top of angiotensin II receptor blockade.
by: Ina M Ott, et al.
Published: (2012-01-01) -
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
by: Michaela Lang, et al.
Published: (2012-01-01) -
Guanylate cyclase signalling in myocardial reperfusion
by: Burley, Dwaine Simon
Published: (2008)