A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women
Background/Aims: Cortisol plays an important role during pregnancy. It controls maternal glucose metabolism and fetal development. Cortisol metabolism is partially controlled by the 11b-HSD2. This enzyme is expressed in the kidney and human placenta. The activity of the enzyme is partially controlle...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Karger Publishers
2014-03-01
|
Series: | Kidney & Blood Pressure Research |
Subjects: | |
Online Access: | http://www.karger.com/Article/FullText/355761 |
id |
doaj-8b373107edd345538e8b8292916fc99f |
---|---|
record_format |
Article |
spelling |
doaj-8b373107edd345538e8b8292916fc99f2020-11-25T03:36:04ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432014-03-0138113214110.1159/000355761355761A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant WomenJian LiYou-Peng ChenZi-Neng WangTie-Bin LiuDan ChenYun-Peng DongBerthold HocherBackground/Aims: Cortisol plays an important role during pregnancy. It controls maternal glucose metabolism and fetal development. Cortisol metabolism is partially controlled by the 11b-HSD2. This enzyme is expressed in the kidney and human placenta. The activity of the enzyme is partially controlled by functional polymorphisms: the HSD11B2[CA]n microsatellite polymorphism. The impact of this functional gene polymorphism on cortisol metabolism and potential effects on the newborn's is unknown so far. Methods: In the current prospective birth cohort study in southern Asia, we analyzed the association of the HSD11B2[CA]n microsatellite polymorphisms in 187 mothers and their newborn's on maternal and newborn's serum cortisol concentrations. Results: Using multivariable regression analyses considering known confounding (gestational age, newborn's gender, the labor uterine contraction states and the timing during the day of blood taking), we showed that the fetal HSD11B2[CA]n microsatellite polymorphisms in the first intron was related to maternal cortisol concentration (R2=0.26, B=96.27, p=0.007), whereas as the newborn's cortisol concentrations were independent of fetal and maternal HSD11B2[CA]n microsatellite polymorphism. Conclusions: Our study showed for the first time that the fetal HSD11B2[CA]n microsatellite polymorphism of the HSD11B2 gene in healthy uncomplicated human pregnancy is associated with maternal cortisol concentration. This indicates that fetal genes controlling cortisol metabolism may affect maternal cortisol concentration and hence physiology in healthy pregnant women.http://www.karger.com/Article/FullText/355761Cortisol l metabolism11 beta-hydroxysteroid dehydrogenase 2HSD11B2[CA]n polymorphismPregnancyPlacenta |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jian Li You-Peng Chen Zi-Neng Wang Tie-Bin Liu Dan Chen Yun-Peng Dong Berthold Hocher |
spellingShingle |
Jian Li You-Peng Chen Zi-Neng Wang Tie-Bin Liu Dan Chen Yun-Peng Dong Berthold Hocher A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women Kidney & Blood Pressure Research Cortisol l metabolism 11 beta-hydroxysteroid dehydrogenase 2 HSD11B2[CA]n polymorphism Pregnancy Placenta |
author_facet |
Jian Li You-Peng Chen Zi-Neng Wang Tie-Bin Liu Dan Chen Yun-Peng Dong Berthold Hocher |
author_sort |
Jian Li |
title |
A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women |
title_short |
A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women |
title_full |
A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women |
title_fullStr |
A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women |
title_full_unstemmed |
A Functional Fetal HSD11B2[CA]n Microsatellite Polymorphism is Associated with Maternal Serum Cortisol Concentrations in Pregnant Women |
title_sort |
functional fetal hsd11b2[ca]n microsatellite polymorphism is associated with maternal serum cortisol concentrations in pregnant women |
publisher |
Karger Publishers |
series |
Kidney & Blood Pressure Research |
issn |
1420-4096 1423-0143 |
publishDate |
2014-03-01 |
description |
Background/Aims: Cortisol plays an important role during pregnancy. It controls maternal glucose metabolism and fetal development. Cortisol metabolism is partially controlled by the 11b-HSD2. This enzyme is expressed in the kidney and human placenta. The activity of the enzyme is partially controlled by functional polymorphisms: the HSD11B2[CA]n microsatellite polymorphism. The impact of this functional gene polymorphism on cortisol metabolism and potential effects on the newborn's is unknown so far. Methods: In the current prospective birth cohort study in southern Asia, we analyzed the association of the HSD11B2[CA]n microsatellite polymorphisms in 187 mothers and their newborn's on maternal and newborn's serum cortisol concentrations. Results: Using multivariable regression analyses considering known confounding (gestational age, newborn's gender, the labor uterine contraction states and the timing during the day of blood taking), we showed that the fetal HSD11B2[CA]n microsatellite polymorphisms in the first intron was related to maternal cortisol concentration (R2=0.26, B=96.27, p=0.007), whereas as the newborn's cortisol concentrations were independent of fetal and maternal HSD11B2[CA]n microsatellite polymorphism. Conclusions: Our study showed for the first time that the fetal HSD11B2[CA]n microsatellite polymorphism of the HSD11B2 gene in healthy uncomplicated human pregnancy is associated with maternal cortisol concentration. This indicates that fetal genes controlling cortisol metabolism may affect maternal cortisol concentration and hence physiology in healthy pregnant women. |
topic |
Cortisol l metabolism 11 beta-hydroxysteroid dehydrogenase 2 HSD11B2[CA]n polymorphism Pregnancy Placenta |
url |
http://www.karger.com/Article/FullText/355761 |
work_keys_str_mv |
AT jianli afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT youpengchen afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT zinengwang afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT tiebinliu afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT danchen afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT yunpengdong afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT bertholdhocher afunctionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT jianli functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT youpengchen functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT zinengwang functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT tiebinliu functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT danchen functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT yunpengdong functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen AT bertholdhocher functionalfetalhsd11b2canmicrosatellitepolymorphismisassociatedwithmaternalserumcortisolconcentrationsinpregnantwomen |
_version_ |
1724551384876974080 |