Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab
We describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab. The first symptoms of PML appeared immediately following the last of five cycles of ritu...
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doaj-8b38a8c88b7646c0bdddb1b183aee0112020-11-24T21:02:06ZengKarger PublishersCase Reports in Oncology1662-65752011-03-014113614210.1159/000326851326851Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with RituximabSubhankar ChakrabortyStefano R. TarantoloJohn TrevesDavid SambolRalph J. HaukeSurinder K. BatraWe describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab. The first symptoms of PML appeared immediately following the last of five cycles of rituximab, cyclophosphamide and pentostatin. Magnetic resonance imaging revealed changes consistent with PML, although JC virus DNA was not detected by polymerase chain reaction assay of the cerebrospinal fluid. A stereotactic biopsy of the brain showed histological changes consistent with PML, while electron microscopy revealed JC virus particles attached to the nuclei of astrocytes. The patient was treated supportively but died 53 days after the initial onset of symptoms.http://www.karger.com/Article/FullText/326851Progressive multifocal leukoencephalopathyRituximabJC virusSmall lymphocytic leukemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Subhankar Chakraborty Stefano R. Tarantolo John Treves David Sambol Ralph J. Hauke Surinder K. Batra |
spellingShingle |
Subhankar Chakraborty Stefano R. Tarantolo John Treves David Sambol Ralph J. Hauke Surinder K. Batra Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab Case Reports in Oncology Progressive multifocal leukoencephalopathy Rituximab JC virus Small lymphocytic leukemia |
author_facet |
Subhankar Chakraborty Stefano R. Tarantolo John Treves David Sambol Ralph J. Hauke Surinder K. Batra |
author_sort |
Subhankar Chakraborty |
title |
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab |
title_short |
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab |
title_full |
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab |
title_fullStr |
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab |
title_full_unstemmed |
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab |
title_sort |
progressive multifocal leukoencephalopathy in a hiv-negative patient with small lymphocytic leukemia following treatment with rituximab |
publisher |
Karger Publishers |
series |
Case Reports in Oncology |
issn |
1662-6575 |
publishDate |
2011-03-01 |
description |
We describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab. The first symptoms of PML appeared immediately following the last of five cycles of rituximab, cyclophosphamide and pentostatin. Magnetic resonance imaging revealed changes consistent with PML, although JC virus DNA was not detected by polymerase chain reaction assay of the cerebrospinal fluid. A stereotactic biopsy of the brain showed histological changes consistent with PML, while electron microscopy revealed JC virus particles attached to the nuclei of astrocytes. The patient was treated supportively but died 53 days after the initial onset of symptoms. |
topic |
Progressive multifocal leukoencephalopathy Rituximab JC virus Small lymphocytic leukemia |
url |
http://www.karger.com/Article/FullText/326851 |
work_keys_str_mv |
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