Inhibiting microRNA‐301b suppresses cell growth and targets RNF38 in cervical carcinoma

• Main Authors: Wen‐Ling Guo, Ning Li, Jian‐Lin Ma, Xue‐Mei Chen, Fan‐Ying Shi
• Format: Article
• Language: English
• Published: Wiley 2020-11-01
• Series: Kaohsiung Journal of Medical Sciences
• Subjects: cell growth; cervical carcinoma; microRNA‐301b; RNF38
• Online Access: https://doi.org/10.1002/kjm2.12273

Abstract It has been reported microRNA‐301b (miR‐301b) was involved in the tumorigenesis of some cancers, but it has not been investigated in cervical carcinoma yet. In this study, miR‐301b was found significantly upregulated in cervical carcinoma, and patients with high miR‐301b expression had a shorter overall survival. When miR‐301b was knocked down in cervical carcinoma cells, the cell growth could be significantly abolished. Our further studies showed miR‐301b targeted RNF38, and inhibited its expression in cervical carcinoma cells. Moreover, RNF38 was found downregulated in cervical carcinoma, and miR‐301b expression in cervical tissues was found negatively correlated with RNF38 expression. In addition, overexpression of RNF38 significantly inhibited cervical carcinoma cell growth, but overexpression of miR‐301b suppressed RNF38‐induced cell growth inhibition in cervical carcinoma. Collectively, this study suggested miR‐301b could be a novel target for cervical carcinoma treatment.