Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study
Background: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil...
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doaj-8b3e0ac2d9c84b54a76fbe4ff84380c22020-12-12T00:05:32ZengMDPI AGJournal of Clinical Medicine2077-03832020-12-0194016401610.3390/jcm9124016Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot StudyTadamichi Akagi0Yoko Okamoto1Takanori Kameda2Kenji Suda3Hideo Nakanishi4Masahiro Miyake5Hanako Ohashi Ikeda6Tatsuya Yamada7Shin Kadomoto8Akihito Uji9Akitaka Tsujikawa10Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto 6068507, JapanBackground: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. Results: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, <i>p </i>=<i> </i>0.004; at 2 h, <i>p </i>= 0.018). Conclusions: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature.https://www.mdpi.com/2077-0383/9/12/4016Anterior segment optical coherence tomography angiographyanti-glaucoma eyedropaqueous humor outflow pathwayintraocular pressure reduction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tadamichi Akagi Yoko Okamoto Takanori Kameda Kenji Suda Hideo Nakanishi Masahiro Miyake Hanako Ohashi Ikeda Tatsuya Yamada Shin Kadomoto Akihito Uji Akitaka Tsujikawa |
spellingShingle |
Tadamichi Akagi Yoko Okamoto Takanori Kameda Kenji Suda Hideo Nakanishi Masahiro Miyake Hanako Ohashi Ikeda Tatsuya Yamada Shin Kadomoto Akihito Uji Akitaka Tsujikawa Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study Journal of Clinical Medicine Anterior segment optical coherence tomography angiography anti-glaucoma eyedrop aqueous humor outflow pathway intraocular pressure reduction |
author_facet |
Tadamichi Akagi Yoko Okamoto Takanori Kameda Kenji Suda Hideo Nakanishi Masahiro Miyake Hanako Ohashi Ikeda Tatsuya Yamada Shin Kadomoto Akihito Uji Akitaka Tsujikawa |
author_sort |
Tadamichi Akagi |
title |
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study |
title_short |
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study |
title_full |
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study |
title_fullStr |
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study |
title_full_unstemmed |
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study |
title_sort |
short-term effects of different types of anti-glaucoma eyedrop on the sclero-conjunctival vasculature assessed using anterior segment octa in normal human eyes: a pilot study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-12-01 |
description |
Background: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. Results: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, <i>p </i>=<i> </i>0.004; at 2 h, <i>p </i>= 0.018). Conclusions: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature. |
topic |
Anterior segment optical coherence tomography angiography anti-glaucoma eyedrop aqueous humor outflow pathway intraocular pressure reduction |
url |
https://www.mdpi.com/2077-0383/9/12/4016 |
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