Use of oral iron in managing iron deficiency anemia in children with intestinal failure
Background & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is c...
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2021-12-01
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doaj-8b47cca1d3e54e489bc6f9be91282a922021-09-23T04:36:26ZengElsevierJournal of King Saud University: Science1018-36472021-12-01338101601Use of oral iron in managing iron deficiency anemia in children with intestinal failureBadr Alsaleem0Nora Albanyan1Ahmad Alamer2Syed Mohammed Basheeruddin Asdaq3Yahya Mohzari4Mohannad M. Alrahili5Amna B. Albasheer6Ahmed A. Alrashed7Abdulhakeem S. Alamri8Walaa F. Alsanie9Majid Alhomrani10Medical Specialties Department, Gastroenterology Section, Children Hospital, King Fahad Medical City, Riyadh, Saudi ArabiaPharmaceutical Service Department, Clinical Pharmacy, King Fahad Medical City, Riyadh, Saudi ArabiaCenter for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA; Department of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, 13713 Riyadh, Saudi Arabia; Corresponding author.Pharmacy Department, Clinical Pharmacy Section, King Saud Medical City, Saudi ArabiaPediatric Department, King Abdulaziz Medical City, Riyadh, Saudi ArabiaPediatric Gastroenterology Section, Children Hospital, King Fahad Medical City, Riyadh, Saudi ArabiaPharmaceutical Service Department, Main Hospital, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi ArabiaDepartment of Clinical Laboratory Sciences, The Faculty of Applied Medical Sciences, Taif University, Taif, Saudi Arabia; Centre of Biomedical Sciences Research (CBSR), Deanship of Scientific Research, Taif University, Saudi ArabiaBackground & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is common. This study used a quasi-experimental approach to assess the efficacy and safety of oral iron therapy in treating IDA in TPN-dependent children with IF. Materials and Methods: Sixteen pediatric patients with an ongoing history of IF, TPN dependency, and iron deficiency anemia were enrolled and given an oral iron syrup dose of ferric hydroxide polymaltose complex (6 mg/kg/day in 2–3 separate doses of elemental iron) after receiving ethical approval and parental consent. Blood tests were done to measure serum iron, ferritin, complete iron-binding capacity [TIBC], transferrin saturation [TSAT], and hemoglobin (Hb) level at the time of inclusion (T0), 14 (T14), and 30 days after treatment (T30). Results: The mean age was 7.13 (±1.99) and female were 12 (75%). No remarkable change in Hb level was noted in the first and second subsequent follow-ups, notwithstanding, the normal estimation of the serum ferritin level significantly increased during the first follow-up (on fourteenth day) which further enhanced by second follow-up (30th day). The aggregate of the total iron binding capacity (TIBC) declined during the course of oral iron therapy with a reduction in transferrin saturation. Interpretation & Conclusion: The data suggest that oral iron therapy is unsuccessful in the treatment of IDA in children with IF. There is no substantial improvement in hemoglobin level or iron profile aside from serum ferritin. In order to avoid using parenteral iron in IF patients, an additional supportive system is needed to aid in the integration of oral iron therapy.http://www.sciencedirect.com/science/article/pii/S1018364721002639Intestinal failureIron deficiency anemiaOral ironTotal parenteral nutritionChildrenFerritin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani |
spellingShingle |
Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani Use of oral iron in managing iron deficiency anemia in children with intestinal failure Journal of King Saud University: Science Intestinal failure Iron deficiency anemia Oral iron Total parenteral nutrition Children Ferritin |
author_facet |
Badr Alsaleem Nora Albanyan Ahmad Alamer Syed Mohammed Basheeruddin Asdaq Yahya Mohzari Mohannad M. Alrahili Amna B. Albasheer Ahmed A. Alrashed Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani |
author_sort |
Badr Alsaleem |
title |
Use of oral iron in managing iron deficiency anemia in children with intestinal failure |
title_short |
Use of oral iron in managing iron deficiency anemia in children with intestinal failure |
title_full |
Use of oral iron in managing iron deficiency anemia in children with intestinal failure |
title_fullStr |
Use of oral iron in managing iron deficiency anemia in children with intestinal failure |
title_full_unstemmed |
Use of oral iron in managing iron deficiency anemia in children with intestinal failure |
title_sort |
use of oral iron in managing iron deficiency anemia in children with intestinal failure |
publisher |
Elsevier |
series |
Journal of King Saud University: Science |
issn |
1018-3647 |
publishDate |
2021-12-01 |
description |
Background & Objectives: As intestinal failure (IF) inhibits the digestive system from absorbing nutrients, total parenteral nutrition (TPN) is required to provide all of a person's nutritional demands. In children with malabsorptive conditions like IF, iron deficiency anemia (IDA) is common. This study used a quasi-experimental approach to assess the efficacy and safety of oral iron therapy in treating IDA in TPN-dependent children with IF. Materials and Methods: Sixteen pediatric patients with an ongoing history of IF, TPN dependency, and iron deficiency anemia were enrolled and given an oral iron syrup dose of ferric hydroxide polymaltose complex (6 mg/kg/day in 2–3 separate doses of elemental iron) after receiving ethical approval and parental consent. Blood tests were done to measure serum iron, ferritin, complete iron-binding capacity [TIBC], transferrin saturation [TSAT], and hemoglobin (Hb) level at the time of inclusion (T0), 14 (T14), and 30 days after treatment (T30). Results: The mean age was 7.13 (±1.99) and female were 12 (75%). No remarkable change in Hb level was noted in the first and second subsequent follow-ups, notwithstanding, the normal estimation of the serum ferritin level significantly increased during the first follow-up (on fourteenth day) which further enhanced by second follow-up (30th day). The aggregate of the total iron binding capacity (TIBC) declined during the course of oral iron therapy with a reduction in transferrin saturation. Interpretation & Conclusion: The data suggest that oral iron therapy is unsuccessful in the treatment of IDA in children with IF. There is no substantial improvement in hemoglobin level or iron profile aside from serum ferritin. In order to avoid using parenteral iron in IF patients, an additional supportive system is needed to aid in the integration of oral iron therapy. |
topic |
Intestinal failure Iron deficiency anemia Oral iron Total parenteral nutrition Children Ferritin |
url |
http://www.sciencedirect.com/science/article/pii/S1018364721002639 |
work_keys_str_mv |
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