Constitutive Expression of the α4 Integrin Correlates with Tumorigenicity and Lymph Node Metastasis of the B16 Murine Melanoma
The lymphatic system plays a critical role in melanoma metastasis, and yet, virtually no information exists regarding the cellular and molecular mechanisms that take place between melanoma cells and the lymphatic vasculature. Here, we generated B16-F1 melanoma cells that expressed high (B16α4+) and...
Main Authors: | Robert B. Rebhun, Hua Cheng, Jeffrey E. Gershenwald, Dominic Fan, Isaiah J. Fidler, Robert R. Langley |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2010-02-01
|
Series: | Neoplasia: An International Journal for Oncology Research |
Online Access: | http://www.sciencedirect.com/science/article/pii/S147655861080096X |
Similar Items
-
Targeting Receptor Tyrosine Kinase on Lymphatic Endothelial Cells for the Therapy of Colon Cancer Lymph Node Metastasis
by: Robert B. Rebhun, et al.
Published: (2006-09-01) -
Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis
by: Jie Chen, et al.
Published: (2012-01-01) -
Prognostic factors of metastasis of skin melanoma to sentinel lymph nodes
by: E. A. Nikolaeva, et al.
Published: (2021-05-01) -
Cutaneous melanoma in childhood presenting as intraparotid lymph node metastasis
by: Abhishek Kumar, et al.
Published: (2018-01-01) -
Predictors of occult lymph node metastasis in cutaneous head and neck melanoma
by: Jonathan S. Ni, et al.
Published: (2019-12-01)