Molluscicidal activity of Physalis angulata L. extracts and fractions on Biomphalaria tenagophila (d'Orbigny, 1835) under laboratory conditions

• Main Authors: José Augusto A dos Santos, Therezinha Coelho B Tomassini, Deise Cristina Drummond Xavier, Ivone Maria Ribeiro, Melissa Teixeira G da Silva, Zenildo Buarque de Morais Filho
• Format: Article
• Language: English
• Published: Instituto Oswaldo Cruz, Ministério da Saúde 2003-04-01
• Series: Memórias do Instituto Oswaldo Cruz.
• Subjects: molluscicidal activity; Physalis angulata L.; Solanaceae; Biomphalaria tenagophila
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000300024
• ISSN: 0074-0276; 1678-8060

The main objective of this research is to evaluate the molluscicide activity of Physalis angulata L. Biomphalaria tenagophila specimens under laboratory conditions. Extracts and fractions were supplied by the Laboratório de Química de Produtos Naturais, Farmanguinhos-Fiocruz. Experiments were performed according to the methodology described by the World Health Organization for molluscicide tests using the concentrations from 0.1 to 500 mg/l of the extracts, fractions and of a pool of physalins modified steroids present in this species. The results show that ethyl acetate and acetone extracts from the whole plant, the ethanolic extracts of the roots and the physalins pool from stems and leaves were active. Only the whole plant extracts were available in sufficient quantity for the determination of LD50 and LD90 values.