Liver cirrhosis and the risk of fracture: a Meta-analysis

• Main Authors: ZHAO Jian, LI Wei, LIANG Caiquan
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2017-06-01
• Series: Linchuang Gandanbing Zazhi
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=8263

ObjectiveTo investigate the association between liver cirrhosis and the risk of fracture from the perspective of evidence-based medicine. MethodsPubMed, Web of Science, Embase, CNKI, Wanfang Data, SinoMed, and VIP were searched to collect published observational studies on the association between liver cirrhosis and fracture. The quality of each study was assessed and RevMan5.3 software was used to perform a meta-analysis of the risk of fracture, and the odds ratio (OR) and 95% confidence interval (CI) were calculated. ResultsThree cohort studies and two cross-sectional studies were included with 28 820 patients in liver cirrhosis group and 214 313 cases in control group. The analysis showed that compared with the control group, the liver cirrhosis group had a significant increase in the overall risk of fracture (all studies: OR=2.07, 95%CI： 1.52-2.83, P＜0.000 01; cohort studies: OR=2.00, 95%CI： 1.93-2.07, P＜0000 01). When the patients were divided according to the type of fracture, compared with the control group, the liver cirrhosis group had significant increases in the risks of vertebral fracture and non-vertebral fracture (upper extremities) (OR=2.10, 95%CI： 1.30-340, P=0.003; OR=1.61, 95%CI： 1.53-1.69, P＜0.000 01). ConclusionLiver cirrhosis may increase the risk of fracture. However, due to the heterogeneity of these studies, the above results need to be further verified by more detailed studies.