Constitutively bound CTCF sites maintain 3D chromatin architecture and long-range epigenetically regulated domains
The architectural protein CTCF is a mediator of chromatin conformation, but how CTCF binding to DNA is regulated remains poorly understood. Here the authors find that there is a shared subset of CTCF-bound sites resistant to protein depletion in different cell lines, which are enriched at domain bou...
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Bibliographic Details
| Main Authors: |
Amanda Khoury,
Joanna Achinger-Kawecka,
Saul A. Bert,
Grady C. Smith,
Hugh J. French,
Phuc-Loi Luu,
Timothy J. Peters,
Qian Du,
Aled J. Parry,
Fatima Valdes-Mora,
Phillippa C. Taberlay,
Clare Stirzaker,
Aaron L. Statham,
Susan J. Clark |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-13753-7
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