Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels
Aptamers are special types of single-stranded DNA generated by a process called systematic evolution of ligands by exponential enrichment (SELEX). Due to significant advances in the chemical synthesis and biotechnological production, aptamers have gained considerable attention as versatile building...
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doaj-8b6e5f46a3c3484bb4cb564103d6f88d2020-11-25T04:00:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-10-01710.3389/fmed.2020.00456571915Design, Bioanalytical, and Biomedical Applications of Aptamer-Based HydrogelsYa Di0Ping Wang1Chunyan Li2Shufeng Xu3Qi Tian4Tong Wu5Yaling Tian6Liming Gao7Department of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaDepartment of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Beijing, ChinaDepartment of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaDepartment of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaDepartment of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaDepartment of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaDepartment of Respiratory Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, ChinaAptamers are special types of single-stranded DNA generated by a process called systematic evolution of ligands by exponential enrichment (SELEX). Due to significant advances in the chemical synthesis and biotechnological production, aptamers have gained considerable attention as versatile building blocks for the next generation of soft materials. Hydrogels are high water-retainable materials with a three-dimensional (3D) polymeric network. Aptamers, as a vital element, have greatly expanded the applications of hydrogels. Due to their biocompatibility, selective binding, and molecular recognition, aptamer-based hydrogels can be utilized for bioanalytical and biomedical applications. In this review, we focus on the latest strategies of aptamer-based hydrogels in bioanalytical and biomedical applications. We begin this review with an overview of the underlying design principles for the construction of aptamer-based hydrogels. Next, we will discuss some bioanalytical and biomedical applications of aptamer-based hydrogel including biosensing, target capture and release, logic devices, gene and cancer therapy. Finally, the recent progress of aptamer-based hydrogels is discussed, along with challenges and future perspectives.https://www.frontiersin.org/articles/10.3389/fmed.2020.00456/fullaptamer-based hydrogelsaptamerhydrogelsbioanalysisbiomedicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ya Di Ping Wang Chunyan Li Shufeng Xu Qi Tian Tong Wu Yaling Tian Liming Gao |
spellingShingle |
Ya Di Ping Wang Chunyan Li Shufeng Xu Qi Tian Tong Wu Yaling Tian Liming Gao Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels Frontiers in Medicine aptamer-based hydrogels aptamer hydrogels bioanalysis biomedicine |
author_facet |
Ya Di Ping Wang Chunyan Li Shufeng Xu Qi Tian Tong Wu Yaling Tian Liming Gao |
author_sort |
Ya Di |
title |
Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels |
title_short |
Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels |
title_full |
Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels |
title_fullStr |
Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels |
title_full_unstemmed |
Design, Bioanalytical, and Biomedical Applications of Aptamer-Based Hydrogels |
title_sort |
design, bioanalytical, and biomedical applications of aptamer-based hydrogels |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Medicine |
issn |
2296-858X |
publishDate |
2020-10-01 |
description |
Aptamers are special types of single-stranded DNA generated by a process called systematic evolution of ligands by exponential enrichment (SELEX). Due to significant advances in the chemical synthesis and biotechnological production, aptamers have gained considerable attention as versatile building blocks for the next generation of soft materials. Hydrogels are high water-retainable materials with a three-dimensional (3D) polymeric network. Aptamers, as a vital element, have greatly expanded the applications of hydrogels. Due to their biocompatibility, selective binding, and molecular recognition, aptamer-based hydrogels can be utilized for bioanalytical and biomedical applications. In this review, we focus on the latest strategies of aptamer-based hydrogels in bioanalytical and biomedical applications. We begin this review with an overview of the underlying design principles for the construction of aptamer-based hydrogels. Next, we will discuss some bioanalytical and biomedical applications of aptamer-based hydrogel including biosensing, target capture and release, logic devices, gene and cancer therapy. Finally, the recent progress of aptamer-based hydrogels is discussed, along with challenges and future perspectives. |
topic |
aptamer-based hydrogels aptamer hydrogels bioanalysis biomedicine |
url |
https://www.frontiersin.org/articles/10.3389/fmed.2020.00456/full |
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