Synthesis, Characterization and Preliminary Anti-inflammatory Evaluation of New Etodolac Derivatives

• Main Authors: Omeed M. Hassan, Susan W. Sarsam
• Format: Article
• Language: English
• Published: College of Pharmacy University of Baghdad 2019-06-01
• Series: Iraqi Journal of Pharmaceutical Sciences
• Subjects: : Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method.
• Online Access: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/942

Three new hydrazone derivatives of Etodolac were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy, and 1HNMR analysis. The synthesis of the target (P1-P3) compounds was accomplished following multistep reaction procedures. The synthesized target compounds were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).