Role of Sam68 in Post-Transcriptional Gene Regulation
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also co...
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doaj-8b7aeb3113bf437e899b379c8264bbc92020-11-24T22:16:08ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-11-011412234022341910.3390/ijms141223402ijms141223402Role of Sam68 in Post-Transcriptional Gene RegulationFlora Sánchez-Jiménez0Víctor Sánchez-Margalet1Department of Medical Biochemistry and Molecular Biology and Immunology, UGC Clinical Biochemistry, Virgen Macarena University Hospital, Avenue. Sánchez Pizjuan 4, Medical School, University of Seville, Seville 41009, SpainDepartment of Medical Biochemistry and Molecular Biology and Immunology, UGC Clinical Biochemistry, Virgen Macarena University Hospital, Avenue. Sánchez Pizjuan 4, Medical School, University of Seville, Seville 41009, SpainThe STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also contains some domains predicted to bind critical components in signal transduction pathways. In response to phosphorylation and other post-transcriptional modifications, Sam68 has been shown to have the ability to link signal transduction pathways to downstream effects regulating RNA metabolism, including transcription, alternative splicing or RNA transport. In addition to its function as a docking protein in some signaling pathways, this prototypic STAR protein has been identified to have a nuclear localization and to take part in the formation of both nuclear and cytosolic multi-molecular complexes such as Sam68 nuclear bodies and stress granules. Coupling with other proteins and RNA targets, Sam68 may play a role in the regulation of differential expression and mRNA processing and translation according to internal and external signals, thus mediating important physiological functions, such as cell death, proliferation or cell differentiation.http://www.mdpi.com/1422-0067/14/12/23402Sam68RNA-binding proteinpost-transcriptional regulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Flora Sánchez-Jiménez Víctor Sánchez-Margalet |
spellingShingle |
Flora Sánchez-Jiménez Víctor Sánchez-Margalet Role of Sam68 in Post-Transcriptional Gene Regulation International Journal of Molecular Sciences Sam68 RNA-binding protein post-transcriptional regulation |
author_facet |
Flora Sánchez-Jiménez Víctor Sánchez-Margalet |
author_sort |
Flora Sánchez-Jiménez |
title |
Role of Sam68 in Post-Transcriptional Gene Regulation |
title_short |
Role of Sam68 in Post-Transcriptional Gene Regulation |
title_full |
Role of Sam68 in Post-Transcriptional Gene Regulation |
title_fullStr |
Role of Sam68 in Post-Transcriptional Gene Regulation |
title_full_unstemmed |
Role of Sam68 in Post-Transcriptional Gene Regulation |
title_sort |
role of sam68 in post-transcriptional gene regulation |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2013-11-01 |
description |
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing family of RNA-binding proteins that also contains some domains predicted to bind critical components in signal transduction pathways. In response to phosphorylation and other post-transcriptional modifications, Sam68 has been shown to have the ability to link signal transduction pathways to downstream effects regulating RNA metabolism, including transcription, alternative splicing or RNA transport. In addition to its function as a docking protein in some signaling pathways, this prototypic STAR protein has been identified to have a nuclear localization and to take part in the formation of both nuclear and cytosolic multi-molecular complexes such as Sam68 nuclear bodies and stress granules. Coupling with other proteins and RNA targets, Sam68 may play a role in the regulation of differential expression and mRNA processing and translation according to internal and external signals, thus mediating important physiological functions, such as cell death, proliferation or cell differentiation. |
topic |
Sam68 RNA-binding protein post-transcriptional regulation |
url |
http://www.mdpi.com/1422-0067/14/12/23402 |
work_keys_str_mv |
AT florasanchezjimenez roleofsam68inposttranscriptionalgeneregulation AT victorsanchezmargalet roleofsam68inposttranscriptionalgeneregulation |
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