Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials
BackgroundThe purpose of this meta-analysis was to compare the safety and efficacy between hypofractionated and conventional fractionation radiotherapy in patients with early-stage breast cancer after breast-conserving surgery.MethodsWe conducted a comprehensive search of PubMed, Embase, Web of Scie...
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2021-10-01
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doaj-8b8d2c6f96634ccf886699854e4104092021-10-01T13:10:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-10-011110.3389/fonc.2021.753209753209Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled TrialsLihu Gu0Lihu Gu1Wei Dai2Rongrong Fu3Hongfeng Lu4Jingyi Shen5Yetan Shi6Mengting Zhang7Ke Jiang8Feng Wu9Department of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Breast Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, ChinaDepartment of General Surgery, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaBackgroundThe purpose of this meta-analysis was to compare the safety and efficacy between hypofractionated and conventional fractionation radiotherapy in patients with early-stage breast cancer after breast-conserving surgery.MethodsWe conducted a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) published before February 2021. At the same time, the hazard ratio (HR), risk ratio (RR), and 95% confidence interval (CI) were calculated to evaluate local recurrence (LR), relapse-free survival (RFS), overall survival (OS), adverse events, and cosmetic outcomes.ResultsA total of 14 articles were included in this meta-analysis. Four thousand eight hundred and sixty-nine patients were randomly assigned to the control group to receive conventional radiotherapy (CFRT); 6,072 patients were randomly assigned to the experimental group and treated with hypofractionated radiotherapy (HFRT). The results showed that there was no statistical difference between HFRT and CFRT in LR (HR = 0.99, 95%CI = 0.97–1.02, p = 0.476), RFS (HR = 0.99, 95%CI = 0.97–1.02, p = 0.485), OS (HR = 1.00, 95%CI = 0.97–1.03, p = 0.879), and cosmetic outcomes (RR = 1.03, 95%CI = 0.95–1.12, p = 0.53). In addition, HFRT showed fewer severe adverse reactions such as acute skin toxicity, induration, breast atrophy, and pain.ConclusionOur results suggest that there is no statistical difference between HFRT and CFRT in terms of LR, RFS, OS, and cosmetic outcomes. HFRT reduces the risk of developing toxicity reactions compared to CFRT. HFRT may be a better option for patients with early breast cancer after breast-conserving surgery.https://www.frontiersin.org/articles/10.3389/fonc.2021.753209/fullbreast cancerhypofractionated radiotherapyconventional fractionated radiotherapybreast-conserving surgerymeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lihu Gu Lihu Gu Wei Dai Rongrong Fu Hongfeng Lu Jingyi Shen Yetan Shi Mengting Zhang Ke Jiang Feng Wu |
spellingShingle |
Lihu Gu Lihu Gu Wei Dai Rongrong Fu Hongfeng Lu Jingyi Shen Yetan Shi Mengting Zhang Ke Jiang Feng Wu Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials Frontiers in Oncology breast cancer hypofractionated radiotherapy conventional fractionated radiotherapy breast-conserving surgery meta-analysis |
author_facet |
Lihu Gu Lihu Gu Wei Dai Rongrong Fu Hongfeng Lu Jingyi Shen Yetan Shi Mengting Zhang Ke Jiang Feng Wu |
author_sort |
Lihu Gu |
title |
Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials |
title_short |
Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials |
title_full |
Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials |
title_fullStr |
Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed |
Comparing Hypofractionated With Conventional Fractionated Radiotherapy After Breast-Conserving Surgery for Early Breast Cancer: A Meta-Analysis of Randomized Controlled Trials |
title_sort |
comparing hypofractionated with conventional fractionated radiotherapy after breast-conserving surgery for early breast cancer: a meta-analysis of randomized controlled trials |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-10-01 |
description |
BackgroundThe purpose of this meta-analysis was to compare the safety and efficacy between hypofractionated and conventional fractionation radiotherapy in patients with early-stage breast cancer after breast-conserving surgery.MethodsWe conducted a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Library to identify relevant randomized controlled trials (RCTs) published before February 2021. At the same time, the hazard ratio (HR), risk ratio (RR), and 95% confidence interval (CI) were calculated to evaluate local recurrence (LR), relapse-free survival (RFS), overall survival (OS), adverse events, and cosmetic outcomes.ResultsA total of 14 articles were included in this meta-analysis. Four thousand eight hundred and sixty-nine patients were randomly assigned to the control group to receive conventional radiotherapy (CFRT); 6,072 patients were randomly assigned to the experimental group and treated with hypofractionated radiotherapy (HFRT). The results showed that there was no statistical difference between HFRT and CFRT in LR (HR = 0.99, 95%CI = 0.97–1.02, p = 0.476), RFS (HR = 0.99, 95%CI = 0.97–1.02, p = 0.485), OS (HR = 1.00, 95%CI = 0.97–1.03, p = 0.879), and cosmetic outcomes (RR = 1.03, 95%CI = 0.95–1.12, p = 0.53). In addition, HFRT showed fewer severe adverse reactions such as acute skin toxicity, induration, breast atrophy, and pain.ConclusionOur results suggest that there is no statistical difference between HFRT and CFRT in terms of LR, RFS, OS, and cosmetic outcomes. HFRT reduces the risk of developing toxicity reactions compared to CFRT. HFRT may be a better option for patients with early breast cancer after breast-conserving surgery. |
topic |
breast cancer hypofractionated radiotherapy conventional fractionated radiotherapy breast-conserving surgery meta-analysis |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.753209/full |
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